Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2527798..2528324 | Replicon | chromosome |
| Accession | NZ_CP025747 | ||
| Organism | Escherichia coli strain ML35 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C1I23_RS13625 | Protein ID | WP_000323025.1 |
| Coordinates | 2527798..2528085 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C1I23_RS13630 | Protein ID | WP_000534858.1 |
| Coordinates | 2528085..2528324 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1I23_RS13585 | 2522822..2523037 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| C1I23_RS26480 | 2523257..2523427 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| C1I23_RS13590 | 2523791..2524006 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| C1I23_RS13595 | 2524307..2524519 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C1I23_RS26105 | 2524574..2524663 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| C1I23_RS13600 | 2524941..2525693 | - | 753 | WP_001047135.1 | antitermination protein | - |
| C1I23_RS13605 | 2525707..2526756 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| C1I23_RS13610 | 2526758..2527036 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| C1I23_RS13615 | 2527103..2527354 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| C1I23_RS13620 | 2527571..2527726 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C1I23_RS13625 | 2527798..2528085 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C1I23_RS13630 | 2528085..2528324 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C1I23_RS13635 | 2528349..2528654 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| C1I23_RS13640 | 2528857..2529189 | + | 333 | WP_001301033.1 | protein FlxA | - |
| C1I23_RS13650 | 2529626..2530939 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| C1I23_RS26305 | 2531708..2531995 | - | 288 | Protein_2506 | hypothetical protein | - |
| C1I23_RS13665 | 2532606..2532962 | - | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
| C1I23_RS13670 | 2532959..2533210 | - | 252 | Protein_2508 | DUF977 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2497634..2556195 | 58561 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T91880 WP_000323025.1 NZ_CP025747:c2528085-2527798 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T91880 NZ_CP025747:c2528085-2527798 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT91880 WP_000534858.1 NZ_CP025747:c2528324-2528085 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT91880 NZ_CP025747:c2528324-2528085 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|