Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 31230..31755 Replicon plasmid pFORC79_2
Accession NZ_CP025737
Organism Salmonella enterica strain FORC_079

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag FORC79_RS24575 Protein ID WP_001159868.1
Coordinates 31450..31755 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag FORC79_RS24570 Protein ID WP_000813634.1
Coordinates 31230..31448 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC79_RS24535 26624..27040 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
FORC79_RS24540 27037..27267 - 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FORC79_RS24545 27532..28032 + 501 WP_000528931.1 hypothetical protein -
FORC79_RS25110 28045..28817 + 773 Protein_31 hypothetical protein -
FORC79_RS24560 28984..30117 + 1134 WP_000545987.1 DUF3800 domain-containing protein -
FORC79_RS24565 30151..30663 - 513 WP_000151784.1 hypothetical protein -
FORC79_RS24570 31230..31448 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FORC79_RS24575 31450..31755 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
FORC79_RS24580 31756..32562 + 807 WP_000016982.1 site-specific integrase -
FORC79_RS24585 33336..34091 + 756 WP_000852146.1 replication initiation protein RepE -
FORC79_RS24590 34679..35845 + 1167 WP_000772446.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99333 99333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T91860 WP_001159868.1 NZ_CP025737:31450-31755 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T91860 NZ_CP025737:31450-31755 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT91860 WP_000813634.1 NZ_CP025737:31230-31448 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT91860 NZ_CP025737:31230-31448 [Salmonella enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References