Detailed information of TA system TA091809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 5028342..5028980
• Replicon: chromosome
• Accession: NZ_CP025707
• Organism: Escherichia coli strain YDC107

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0D8WF76
• Locus tag: YDC107_RS24570
• Protein ID: WP_001306887.1
• Coordinates: 5028342..5028518 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: YDC107_RS24575
• Protein ID: WP_001270286.1
• Coordinates: 5028564..5028980 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YDC107_RS24545	5023398..5023856	+	459	WP_000526135.1	IS200/IS605 family transposase	-
YDC107_RS24550	5023964..5025175	-	1212	WP_023143671.1	BenE family transporter YdcO	-
YDC107_RS24555	5025228..5025764	+	537	WP_020233877.1	DNA-binding transcriptional regulator SutR	-
YDC107_RS24560	5025837..5027798	+	1962	WP_024166512.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
YDC107_RS24565	5027890..5028120	-	231	WP_000494241.1	YncJ family protein	-
YDC107_RS24570	5028342..5028518	+	177	WP_001306887.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
YDC107_RS24575	5028564..5028980	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
YDC107_RS24580	5029059..5030465	+	1407	WP_001523229.1	PLP-dependent aminotransferase family protein	-
YDC107_RS24585	5030710..5031855	+	1146	WP_105955873.1	ABC transporter substrate-binding protein	-
YDC107_RS24590	5031873..5032886	+	1014	WP_001523231.1	ABC transporter ATP-binding protein	-
YDC107_RS24595	5032887..5033839	+	953	Protein_4792	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6768.88 Da
• Isoelectric Point: 11.5336

>T91809 WP_001306887.1 NZ_CP025707:5028342-5028518 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFRGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T91809 NZ_CP025707:5028342-5028518 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT91809 WP_001270286.1 NZ_CP025707:5028564-5028980 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT91809 NZ_CP025707:5028564-5028980 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0D8WF76