Detailed information of TA system TA091801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 4334051..4334756
• Replicon: chromosome
• Accession: NZ_CP025707
• Organism: Escherichia coli strain YDC107

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: YDC107_RS21050
• Protein ID: WP_000539521.1
• Coordinates: 4334370..4334756 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: YDC107_RS21045
• Protein ID: WP_001280945.1
• Coordinates: 4334051..4334380 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YDC107_RS21030	4329208..4330119	+	912	WP_001236019.1	glutathione ABC transporter permease GsiD	-
YDC107_RS21035	4330297..4332645	+	2349	WP_105955879.1	EAL domain-containing protein	-
YDC107_RS21040	4332653..4333981	+	1329	WP_000086873.1	GGDEF domain-containing protein	-
YDC107_RS21045	4334051..4334380	-	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
YDC107_RS21050	4334370..4334756	-	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YDC107_RS21055	4334982..4336307	-	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
YDC107_RS21060	4336520..4336903	+	384	WP_000497137.1	biofilm formation regulator BssR	-
YDC107_RS21065	4337014..4338129	+	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
YDC107_RS21070	4338126..4338752	-	627	WP_020233670.1	glutathione S-transferase GstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T91801 WP_000539521.1 NZ_CP025707:c4334756-4334370 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T91801 NZ_CP025707:c4334756-4334370 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT91801 WP_001280945.1 NZ_CP025707:c4334380-4334051 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT91801 NZ_CP025707:c4334380-4334051 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6