Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3706671..3708381 Replicon chromosome
Accession NZ_CP025707
Organism Escherichia coli strain YDC107

Toxin (Protein)


Gene name mosT Uniprot ID A0A829L165
Locus tag YDC107_RS18185 Protein ID WP_001521912.1
Coordinates 3707461..3708381 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag YDC107_RS18180 Protein ID WP_023144380.1
Coordinates 3706671..3707474 (+) Length 268 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YDC107_RS18155 3702001..3702159 - 159 Protein_3535 integrase -
YDC107_RS18160 3702251..3702353 - 103 Protein_3536 transcriptional regulator -
YDC107_RS18165 3702350..3702820 - 471 WP_000201185.1 hypothetical protein -
YDC107_RS18170 3702866..3703006 - 141 WP_001308408.1 ash family protein -
YDC107_RS18175 3703167..3706376 - 3210 WP_020233732.1 RNA-directed DNA polymerase -
YDC107_RS18180 3706671..3707474 + 804 WP_023144380.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
YDC107_RS18185 3707461..3708381 + 921 WP_001521912.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
YDC107_RS18190 3708464..3708709 - 246 Protein_3542 hypothetical protein -
YDC107_RS18195 3708815..3709699 - 885 WP_001119037.1 LysR family transcriptional regulator -
YDC107_RS18200 3709964..3711022 + 1059 WP_122452191.1 alpha/beta hydrolase -
YDC107_RS18205 3711164..3712291 + 1128 WP_001521913.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(12-98)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34601.04 Da        Isoelectric Point: 7.2649

>T91799 WP_001521912.1 NZ_CP025707:3707461-3708381 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Download         Length: 921 bp

>T91799 NZ_CP025707:3707461-3708381 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATACAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 268 a.a.        Molecular weight: 30050.50 Da        Isoelectric Point: 8.9925

>AT91799 WP_023144380.1 NZ_CP025707:3706671-3707474 [Escherichia coli]
MSIQRRQLPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKP
VRVAGLTSLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPE
LVAYEIACGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQFIDQSGIETGTGKRQII
PGGWLEPDYQITVPRAFKPEGVEDGSA

Download         Length: 804 bp

>AT91799 NZ_CP025707:3706671-3707474 [Escherichia coli]
ATGTCTATTCAGAGGCGACAGTTGCCAAACTATCTAAACTGGCTGATGCAGCACACGCTACCCGGCCAGGTGCTGCTCCA
GTCATGGCTTACCCGCAACGGCATAGATCGTAAGCTCTCTTATCTCTATGTGAAGAATGGCTGGCTCAGGCGGATCGCTC
ACGGCGTATACTGCCGGACGGGTCGTGAACCGGATTGGGTGGATGCGGTTTACTGCCTGCAATCGCAGTGGGAAAAGCCT
GTTCGGGTGGCGGGGCTAACCAGCCTTGCGCTTCAGGGTCATGCGCACTATACCGAACAGGGTAAGCCGCAGGTCTGGCT
CGCGCTTCCGGCTTACGTCAAACTGCCGGGATGGTTTTCTGCCTTTGAACAATCCGCAACATTTGTCACGCTGTATACGT
CAGGCCTTACCGCTGATGTAACGCCATTTACTACGGAACTGAAAATTGGTGACCGGCAGTTAGCGGGCAGTGTCCCGGAA
CTGGTCGCGTATGAGATCGCTTGTGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGATGAA
TCTTCTCAGCCCGCGTAAATTGCAGGCGTTACTCTGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTG
CCCGGCGTAATGGACACCCTTATTTTCAGTTTATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATA
CCCGGCGGCTGGCTGGAGCCGGATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGC
GTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L165

Antitoxin

Source ID Structure

References