Detailed information of TA system TA091798

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3697901..3698736
• Replicon: chromosome
• Accession: NZ_CP025707
• Organism: Escherichia coli strain YDC107

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1EZ92
• Locus tag: YDC107_RS18130
• Protein ID: WP_000854726.1
• Coordinates: 3698359..3698736 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: YDC107_RS18125
• Protein ID: WP_105955847.1
• Coordinates: 3697901..3698269 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YDC107_RS18100	3694135..3695007	+	873	WP_001407301.1	GTPase family protein	-
YDC107_RS18105	3695379..3696416	+	1038	WP_105955846.1	AIDA repeat-containing protein	-
YDC107_RS18110	3696432..3696908	+	477	WP_001186727.1	RadC family protein	-
YDC107_RS18115	3696971..3697192	+	222	WP_000692346.1	DUF987 domain-containing protein	-
YDC107_RS18120	3697207..3697851	+	645	Protein_3528	antitoxin of toxin-antitoxin stability system	-
YDC107_RS18125	3697901..3698269	+	369	WP_105955847.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
YDC107_RS18130	3698359..3698736	+	378	WP_000854726.1	TA system toxin CbtA family protein	Toxin
YDC107_RS18135	3698733..3699221	+	489	WP_042047259.1	hypothetical protein	-
YDC107_RS18140	3699233..3699430	+	198	WP_000839267.1	DUF957 domain-containing protein	-
YDC107_RS18145	3699515..3700363	+	849	WP_042047262.1	DUF4942 domain-containing protein	-
YDC107_RS18150	3700456..3701775	-	1320	WP_020233731.1	site-specific integrase	-
YDC107_RS18155	3702001..3702159	-	159	Protein_3535	integrase	-
YDC107_RS18160	3702251..3702353	-	103	Protein_3536	transcriptional regulator	-
YDC107_RS18165	3702350..3702820	-	471	WP_000201185.1	hypothetical protein	-
YDC107_RS18170	3702866..3703006	-	141	WP_001308408.1	ash family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3678223..3706376	28153

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14164.10 Da
• Isoelectric Point: 7.8045

>T91798 WP_000854726.1 NZ_CP025707:3698359-3698736 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T91798 NZ_CP025707:3698359-3698736 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13578.37 Da
• Isoelectric Point: 6.6255

>AT91798 WP_105955847.1 NZ_CP025707:3697901-3698269 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT91798 NZ_CP025707:3697901-3698269 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGGTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: S1EZ92