Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3205133..3205947 Replicon chromosome
Accession NZ_CP025707
Organism Escherichia coli strain YDC107

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag YDC107_RS15715 Protein ID WP_001054376.1
Coordinates 3205690..3205947 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag YDC107_RS15710 Protein ID WP_001309181.1
Coordinates 3205133..3205678 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YDC107_RS15685 3200824..3202137 - 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -
YDC107_RS15690 3202149..3202430 - 282 WP_024165496.1 PTS sugar transporter subunit IIB -
YDC107_RS15695 3202424..3203545 - 1122 WP_000010829.1 M42 family metallopeptidase -
YDC107_RS15700 3203944..3204204 - 261 Protein_3055 hypothetical protein -
YDC107_RS15705 3204331..3205077 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
YDC107_RS15710 3205133..3205678 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
YDC107_RS15715 3205690..3205947 - 258 WP_001054376.1 hypothetical protein Toxin
YDC107_RS15720 3206324..3206569 - 246 Protein_3059 GNAT family N-acetyltransferase -
YDC107_RS15725 3206939..3207925 + 987 WP_001323209.1 hypothetical protein -
YDC107_RS15730 3208508..3209488 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
YDC107_RS15735 3209553..3210659 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T91795 WP_001054376.1 NZ_CP025707:c3205947-3205690 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T91795 NZ_CP025707:c3205947-3205690 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT91795 WP_001309181.1 NZ_CP025707:c3205678-3205133 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT91795 NZ_CP025707:c3205678-3205133 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References