Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1691412..1692247 | Replicon | chromosome |
Accession | NZ_CP025707 | ||
Organism | Escherichia coli strain YDC107 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A2I6T1R7 |
Locus tag | YDC107_RS08415 | Protein ID | WP_016231184.1 |
Coordinates | 1691870..1692247 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A7Z1I923 |
Locus tag | YDC107_RS08410 | Protein ID | WP_016231183.1 |
Coordinates | 1691412..1691780 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
YDC107_RS08360 | 1687398..1687745 | - | 348 | WP_000612617.1 | IS66 family insertion sequence element accessory protein TnpB | - |
YDC107_RS08365 | 1687742..1688146 | - | 405 | WP_016231180.1 | IS66 family insertion sequence hypothetical protein | - |
YDC107_RS08370 | 1688232..1688465 | + | 234 | WP_001119719.1 | DUF905 family protein | - |
YDC107_RS08375 | 1688410..1688544 | + | 135 | WP_071602470.1 | cytoplasmic protein | - |
YDC107_RS08380 | 1688565..1689383 | + | 819 | WP_023909039.1 | DUF945 domain-containing protein | - |
YDC107_RS08385 | 1689438..1689923 | + | 486 | WP_000849596.1 | antirestriction protein | - |
YDC107_RS08390 | 1689939..1690415 | + | 477 | WP_001186774.1 | RadC family protein | - |
YDC107_RS08395 | 1690478..1690699 | + | 222 | WP_016231182.1 | DUF987 domain-containing protein | - |
YDC107_RS08400 | 1690760..1691053 | - | 294 | WP_071807124.1 | hypothetical protein | - |
YDC107_RS08405 | 1691078..1691362 | + | 285 | WP_001172104.1 | hypothetical protein | - |
YDC107_RS08410 | 1691412..1691780 | + | 369 | WP_016231183.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
YDC107_RS08415 | 1691870..1692247 | + | 378 | WP_016231184.1 | TA system toxin CbtA family protein | Toxin |
YDC107_RS08420 | 1692244..1692732 | + | 489 | WP_016231185.1 | hypothetical protein | - |
YDC107_RS08425 | 1692744..1692941 | + | 198 | WP_016231186.1 | DUF957 domain-containing protein | - |
YDC107_RS08430 | 1693038..1693607 | + | 570 | WP_016231187.1 | DUF4942 domain-containing protein | - |
YDC107_RS08435 | 1693949..1694119 | + | 171 | Protein_1648 | IS110 family transposase | - |
YDC107_RS08440 | 1694930..1695913 | + | 984 | WP_001298261.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
YDC107_RS08445 | 1695985..1697133 | + | 1149 | WP_000905926.1 | capsule polysaccharide export inner-membrane protein KpsE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14106.07 Da Isoelectric Point: 8.2905
>T91788 WP_016231184.1 NZ_CP025707:1691870-1692247 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T91788 NZ_CP025707:1691870-1692247 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13613.43 Da Isoelectric Point: 6.8413
>AT91788 WP_016231183.1 NZ_CP025707:1691412-1691780 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
Download Length: 369 bp
>AT91788 NZ_CP025707:1691412-1691780 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACAACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACAACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2I6T1R7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7Z1I923 |