Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1691412..1692247 Replicon chromosome
Accession NZ_CP025707
Organism Escherichia coli strain YDC107

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2I6T1R7
Locus tag YDC107_RS08415 Protein ID WP_016231184.1
Coordinates 1691870..1692247 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7Z1I923
Locus tag YDC107_RS08410 Protein ID WP_016231183.1
Coordinates 1691412..1691780 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YDC107_RS08360 1687398..1687745 - 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -
YDC107_RS08365 1687742..1688146 - 405 WP_016231180.1 IS66 family insertion sequence hypothetical protein -
YDC107_RS08370 1688232..1688465 + 234 WP_001119719.1 DUF905 family protein -
YDC107_RS08375 1688410..1688544 + 135 WP_071602470.1 cytoplasmic protein -
YDC107_RS08380 1688565..1689383 + 819 WP_023909039.1 DUF945 domain-containing protein -
YDC107_RS08385 1689438..1689923 + 486 WP_000849596.1 antirestriction protein -
YDC107_RS08390 1689939..1690415 + 477 WP_001186774.1 RadC family protein -
YDC107_RS08395 1690478..1690699 + 222 WP_016231182.1 DUF987 domain-containing protein -
YDC107_RS08400 1690760..1691053 - 294 WP_071807124.1 hypothetical protein -
YDC107_RS08405 1691078..1691362 + 285 WP_001172104.1 hypothetical protein -
YDC107_RS08410 1691412..1691780 + 369 WP_016231183.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
YDC107_RS08415 1691870..1692247 + 378 WP_016231184.1 TA system toxin CbtA family protein Toxin
YDC107_RS08420 1692244..1692732 + 489 WP_016231185.1 hypothetical protein -
YDC107_RS08425 1692744..1692941 + 198 WP_016231186.1 DUF957 domain-containing protein -
YDC107_RS08430 1693038..1693607 + 570 WP_016231187.1 DUF4942 domain-containing protein -
YDC107_RS08435 1693949..1694119 + 171 Protein_1648 IS110 family transposase -
YDC107_RS08440 1694930..1695913 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
YDC107_RS08445 1695985..1697133 + 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14106.07 Da        Isoelectric Point: 8.2905

>T91788 WP_016231184.1 NZ_CP025707:1691870-1692247 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T91788 NZ_CP025707:1691870-1692247 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13613.43 Da        Isoelectric Point: 6.8413

>AT91788 WP_016231183.1 NZ_CP025707:1691412-1691780 [Escherichia coli]
MSDTLPGTTLPDNNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT91788 NZ_CP025707:1691412-1691780 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACAACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I6T1R7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1I923

References