Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 51514..52040 | Replicon | chromosome |
| Accession | NZ_CP025707 | ||
| Organism | Escherichia coli strain YDC107 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | YDC107_RS00345 | Protein ID | WP_000323025.1 |
| Coordinates | 51514..51801 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | YDC107_RS00350 | Protein ID | WP_000534858.1 |
| Coordinates | 51801..52040 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YDC107_RS00300 | 46538..46753 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| YDC107_RS00305 | 47507..47722 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| YDC107_RS00310 | 48023..48235 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| YDC107_RS00315 | 48290..48379 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| YDC107_RS00320 | 48657..49409 | - | 753 | Protein_63 | antitermination protein | - |
| YDC107_RS00325 | 49423..50472 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| YDC107_RS00330 | 50474..50752 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| YDC107_RS00335 | 50819..51070 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| YDC107_RS00340 | 51287..51442 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| YDC107_RS00345 | 51514..51801 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| YDC107_RS00350 | 51801..52040 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| YDC107_RS00355 | 52065..52370 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| YDC107_RS00360 | 52573..52905 | + | 333 | WP_001301033.1 | protein FlxA | - |
| YDC107_RS00365 | 53342..54655 | - | 1314 | WP_105955755.1 | ISNCY family transposase | - |
| YDC107_RS00370 | 54833..55015 | + | 183 | WP_000955178.1 | hypothetical protein | - |
| YDC107_RS00375 | 54990..55169 | - | 180 | WP_000786209.1 | hypothetical protein | - |
| YDC107_RS00380 | 55933..56337 | + | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| YDC107_RS00385 | 56334..56681 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 156..68827 | 68671 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T91775 WP_000323025.1 NZ_CP025707:c51801-51514 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T91775 NZ_CP025707:c51801-51514 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT91775 WP_000534858.1 NZ_CP025707:c52040-51801 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT91775 NZ_CP025707:c52040-51801 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|