91773

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1717093..1718666 Replicon chromosome
Accession NZ_CP025706
Organism Aeromonas caviae strain T25-39

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C1C91_RS08430 Protein ID WP_119197107.1
Coordinates 1717347..1718666 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C1C91_RS08425 Protein ID WP_052814475.1
Coordinates 1717093..1717347 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1C91_RS08385 (C1C91_08295) 1712391..1712906 - 516 WP_258057385.1 helicase RepA family protein -
C1C91_RS08390 (C1C91_08300) 1713030..1713227 + 198 Protein_1593 transposase -
C1C91_RS08395 (C1C91_08305) 1713527..1714422 + 896 Protein_1594 IS3-like element ISAs22 family transposase -
C1C91_RS08400 1714565..1714684 + 120 WP_258057386.1 hypothetical protein -
C1C91_RS08405 (C1C91_08310) 1714668..1714991 + 324 WP_119197105.1 hypothetical protein -
C1C91_RS08410 (C1C91_08315) 1714976..1715605 - 630 WP_119197106.1 recombinase family protein -
C1C91_RS08415 (C1C91_08320) 1716053..1716502 + 450 WP_080989821.1 nucleotidyltransferase domain-containing protein -
C1C91_RS08420 (C1C91_08325) 1716495..1716923 + 429 WP_052814476.1 DUF86 domain-containing protein -
C1C91_RS08425 (C1C91_08330) 1717093..1717347 + 255 WP_052814475.1 helix-turn-helix domain-containing protein Antitoxin
C1C91_RS08430 (C1C91_08335) 1717347..1718666 + 1320 WP_119197107.1 type II toxin-antitoxin system HipA family toxin Toxin
C1C91_RS08435 (C1C91_08340) 1719068..1720396 - 1329 WP_010676218.1 IS4 family transposase -
C1C91_RS08440 (C1C91_08345) 1720524..1722506 - 1983 WP_119197108.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
C1C91_RS08445 (C1C91_08350) 1722503..1723396 - 894 WP_180321351.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1713030..1720396 7366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49554.57 Da        Isoelectric Point: 7.0587

>T91773 WP_119197107.1 NZ_CP025706:1717347-1718666 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLHGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFDGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFDRSAMEEILTELANSV
DDVIERVTQQLPAGFPYAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T91773 NZ_CP025706:1717347-1718666 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACGACCAGCGGCGCCCATCAGTTTCA
GTACCACGAGTCATGGCTGGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACAGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCTTCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATCTCCATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATAATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCGGGGATCACTGACATAATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATTCTATCTGTCTATCCAGTGTTTGACGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGATCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGGCTTCCCCTATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT91773 WP_052814475.1 NZ_CP025706:1717093-1717347 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSDSPAAGW
KEEW

Download         Length: 255 bp

>AT91773 NZ_CP025706:1717093-1717347 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCATCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCTGATAGTCCGGCAGCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References