Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 266799..268375 Replicon chromosome
Accession NZ_CP025705
Organism Aeromonas caviae strain R25-6

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C1C92_RS01325 Protein ID WP_113068876.1
Coordinates 267053..268375 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C1C92_RS01320 Protein ID WP_113068875.1
Coordinates 266799..267053 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1C92_RS01305 262146..262935 - 790 Protein_249 IS5 family transposase -
C1C92_RS01310 263106..264827 + 1722 WP_113068873.1 AAA family ATPase -
C1C92_RS01315 264830..266455 + 1626 WP_113068874.1 ATP-dependent helicase -
C1C92_RS01320 266799..267053 + 255 WP_113068875.1 helix-turn-helix domain-containing protein Antitoxin
C1C92_RS01325 267053..268375 + 1323 WP_113068876.1 type II toxin-antitoxin system HipA family toxin Toxin
C1C92_RS01330 268800..270269 - 1470 WP_113068877.1 hypothetical protein -
C1C92_RS01335 270214..272778 - 2565 WP_113068878.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 261530..278107 16577
- flank IS/Tn - - 262077..262709 632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49530.09 Da        Isoelectric Point: 8.0907

>T91771 WP_113068876.1 NZ_CP025705:267053-268375 [Aeromonas caviae]
MANLWVYMNGYRVGTFTMTTSGAHQFQYDESWVTLPGSRPISLSMPLRQQCYRGDEPYNFFGNLLPDNLEVKNRVVARYQ
ANSTQSFDLLSCIGQDCVGALQLVAQGAPTPDVKRIECKPLSDAELEHILTSYQQGIPLGMVREVEDFRISIAGAQEKTA
LLYRDNRWYLPSAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFIMQVGKIKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSVRKYESHGGPSIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPGGSFRLTPFYDILSMYPAFGGRGLHPRDAKLAMGLTASKGKIYAIDHIFPCHFYRTAKAVGFEQAKMKRIIAEFIGNL
DMVISNVRAKLPDTFPPRITESILKGLTTRIQRLDLSSIE

Download         Length: 1323 bp

>T91771 NZ_CP025705:267053-268375 [Aeromonas caviae]
ATGGCTAACCTTTGGGTATACATGAACGGTTACCGAGTGGGTACCTTTACCATGACAACTAGCGGTGCCCACCAATTTCA
GTACGATGAGTCTTGGGTAACACTGCCGGGTAGCCGCCCCATTTCTCTCTCTATGCCGTTACGGCAGCAGTGCTATCGAG
GCGATGAGCCCTATAACTTCTTCGGCAACTTGTTGCCGGATAATCTAGAAGTAAAAAACCGGGTGGTAGCACGTTACCAA
GCCAACTCAACCCAATCTTTTGATCTGCTCAGCTGCATTGGTCAGGACTGCGTAGGTGCATTGCAACTGGTGGCTCAGGG
TGCCCCTACGCCTGATGTGAAACGCATCGAATGTAAACCGCTCTCTGATGCTGAACTGGAGCATATCCTGACTAGTTACC
AACAAGGGATCCCTCTTGGGATGGTCAGGGAAGTTGAGGATTTCCGGATCTCTATCGCCGGGGCTCAGGAAAAGACCGCG
CTACTCTATCGTGACAACCGCTGGTACTTACCGAGTGCTGCGACCCCAACCACCCATATCATCAAGTTACCCATTGGTAA
GATCGAGAGCCACTCTTACTCGATAGATCTCTCCCAGAGCGTGGAGAACGAGTATCTCTGTACCCTGATAGCTAAAGAGT
TTGGTCTTCCCGTCCCGCATTGCTTCATTATGCAGGTAGGTAAGATCAAGGCTTTGGCAGTGGAGCGCTTCGATCGACGC
TACGCCGCTGATCGTAGCTGGATCATGCGTCTACCCCAAGAGGACTTCTGCCAAGTATTGAATGTACCGTCAGTACGGAA
GTACGAGAGCCATGGTGGGCCGAGTATTGCTGACATCATGACGACCCTGTTGGGGTCTGCCACACCGGAGCAGGATCGTT
ACCTGTTTATGAAGTCTCAAGTGCTGTTCTGGCTGCTGGCCGCGACTGACGGTCATGCAAAGAACTTCTCGGTCTTTATA
GAACCGGGGGGAAGCTTCCGACTGACACCATTTTACGACATTCTCTCTATGTATCCTGCATTTGGTGGTCGAGGGTTACA
TCCCCGAGATGCCAAACTGGCAATGGGACTTACCGCATCCAAGGGTAAGATATACGCGATAGACCATATATTTCCCTGCC
ATTTCTACCGTACAGCCAAAGCCGTTGGCTTTGAACAGGCGAAGATGAAACGGATTATCGCTGAGTTCATCGGCAATCTG
GATATGGTGATATCGAACGTTCGTGCGAAATTACCTGACACATTTCCCCCCCGAATTACGGAGTCCATCTTGAAAGGGCT
CACTACTAGGATCCAACGCCTTGATCTCTCCTCAATCGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 8.4810

>AT91771 WP_113068875.1 NZ_CP025705:266799-267053 [Aeromonas caviae]
MKVTSAKQLSAYLKDARLLQKYSQGKVADKVGIRQDTVSNFELNPESTKLDTLFKILAALELSLDIKPRTDPPDSPSSGW
KEEW

Download         Length: 255 bp

>AT91771 NZ_CP025705:266799-267053 [Aeromonas caviae]
ATGAAAGTAACCAGCGCGAAGCAGCTTAGTGCCTACCTCAAAGATGCCAGGCTTTTGCAAAAATATTCTCAGGGCAAGGT
TGCCGACAAGGTTGGCATCAGACAAGACACCGTCTCCAATTTTGAGCTCAATCCAGAATCAACCAAGTTGGATACCTTGT
TCAAAATCCTCGCCGCGTTGGAACTATCCCTTGATATCAAGCCTCGAACCGATCCACCGGATAGCCCTTCCTCAGGCTGG
AAAGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References