Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2824151..2824783 Replicon chromosome
Accession NZ_CP025689
Organism Sporolactobacillus terrae strain DRG1

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U1QR24
Locus tag C0679_RS13460 Protein ID WP_010025898.1
Coordinates 2824151..2824501 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U1QQW7
Locus tag C0679_RS13465 Protein ID WP_010025899.1
Coordinates 2824505..2824783 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0679_RS13440 2821038..2821826 - 789 WP_037582118.1 RNA polymerase sigma factor SigB -
C0679_RS13445 2821798..2822277 - 480 WP_028984087.1 anti-sigma B factor RsbW -
C0679_RS13450 2822270..2822608 - 339 WP_028975631.1 STAS domain-containing protein -
C0679_RS13455 2822672..2823670 - 999 WP_028984086.1 SpoIIE family protein phosphatase -
C0679_RS13460 2824151..2824501 - 351 WP_010025898.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
C0679_RS13465 2824505..2824783 - 279 WP_010025899.1 antitoxin Antitoxin
C0679_RS13470 2824944..2826134 - 1191 WP_028984085.1 alanine racemase -
C0679_RS13475 2826372..2827382 - 1011 WP_128167161.1 outer membrane lipoprotein carrier protein LolA -
C0679_RS13480 2827430..2828944 - 1515 WP_128167163.1 NAD(P)H-hydrate dehydratase -
C0679_RS13485 2829000..2829362 - 363 WP_028984082.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12929.96 Da        Isoelectric Point: 6.4684

>T91735 WP_010025898.1 NZ_CP025689:c2824501-2824151 [Sporolactobacillus terrae]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHVEIDAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMGQVNKAIQISLSLIDF

Download         Length: 351 bp

>T91735 NZ_CP025689:c2824501-2824151 [Sporolactobacillus terrae]
GTGATTGTTAAACGCGGCGACGTCTACTTTGCAGATCTCTCTCCGGTTGTCGGATCGGAACAGGGCGGGGTCCGCCCCGT
TCTGATCATCCAGAATGACATTGGCAATCGCTTTAGCCCAACGGTTGTTGTGGCGGCTATCACCGCCCAAATTCAAAAAG
CCAAATTGCCGACTCATGTGGAGATCGATGCAAAACGGTACGGATTCGATCGCGACTCGGTTATCTTGCTTGAGCAGATC
AGAACCATTGACAAGCAGCGACTGACGGATAAAATCACGCATCTAGACGAAGAAATGATGGGCCAAGTAAATAAAGCCAT
TCAGATCAGTCTGAGTTTGATTGACTTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10759.43 Da        Isoelectric Point: 6.4768

>AT91735 WP_010025899.1 NZ_CP025689:c2824783-2824505 [Sporolactobacillus terrae]
MSESKIKEIMLSLPQHLLNEIDGMASRDKMNRSEFLHRAIRLYLRERNRGYVREIMRQGYMEMAKINLNLASEAFLAEEE
AEITLERSVSGV

Download         Length: 279 bp

>AT91735 NZ_CP025689:c2824783-2824505 [Sporolactobacillus terrae]
ATGTCGGAATCGAAGATAAAAGAAATCATGCTGAGTTTGCCGCAACATTTATTGAACGAGATTGATGGAATGGCAAGTCG
AGACAAGATGAATCGCAGCGAATTTCTCCATCGCGCCATCAGGTTGTATCTGCGTGAGCGTAATAGGGGCTATGTCCGTG
AAATTATGCGTCAGGGCTACATGGAAATGGCTAAAATTAATCTAAATCTTGCTTCTGAAGCTTTTCTTGCTGAAGAGGAG
GCAGAGATCACACTGGAACGCTCCGTCAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1QR24

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1QQW7

References