Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1111278..1111771 Replicon chromosome
Accession NZ_CP025685
Organism Enterococcus faecium strain CBA7134

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag C0649_RS05715 Protein ID WP_002329323.1
Coordinates 1111505..1111771 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag C0649_RS05710 Protein ID WP_002329324.1
Coordinates 1111278..1111508 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0649_RS05670 1106282..1107049 + 768 WP_002329331.1 MurR/RpiR family transcriptional regulator -
C0649_RS05675 1107050..1107493 + 444 WP_002329330.1 hypothetical protein -
C0649_RS05680 1107703..1108293 - 591 WP_070544112.1 glutamine amidotransferase -
C0649_RS05685 1108940..1109899 - 960 WP_128251758.1 IS30-like element IS6770 family transposase -
C0649_RS05690 1110149..1110454 + 306 WP_002329327.1 hypothetical protein -
C0649_RS05695 1110467..1110802 + 336 WP_002329326.1 hypothetical protein -
C0649_RS05710 1111278..1111508 + 231 WP_002329324.1 hypothetical protein Antitoxin
C0649_RS05715 1111505..1111771 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0649_RS05720 1112023..1112250 + 228 WP_002329322.1 hypothetical protein -
C0649_RS05725 1112266..1113432 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
C0649_RS05730 1113665..1114708 + 1044 WP_002329320.1 heat-inducible transcriptional repressor HrcA -
C0649_RS05735 1114802..1115365 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1108940..1109899 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T91733 WP_002329323.1 NZ_CP025685:1111505-1111771 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T91733 NZ_CP025685:1111505-1111771 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT91733 WP_002329324.1 NZ_CP025685:1111278-1111508 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT91733 NZ_CP025685:1111278-1111508 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References