Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3085500..3086068 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0099_RS15110 Protein ID WP_102248195.1
Coordinates 3085500..3085871 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0099_RS15115 Protein ID WP_102248196.1
Coordinates 3085868..3086068 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS15090 3081006..3081677 - 672 WP_102248193.1 Cupredoxin -
C0099_RS15095 3081813..3083378 - 1566 WP_164084951.1 transporter substrate-binding domain-containing protein -
C0099_RS15100 3083652..3084851 - 1200 WP_199797678.1 group II intron reverse transcriptase/maturase -
C0099_RS15110 3085500..3085871 - 372 WP_102248195.1 type II toxin-antitoxin system VapC family toxin Toxin
C0099_RS15115 3085868..3086068 - 201 WP_102248196.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C0099_RS15120 3086172..3086618 - 447 WP_199797633.1 HD domain-containing protein -
C0099_RS15125 3086732..3087832 + 1101 WP_164084952.1 PAS domain-containing sensor histidine kinase -
C0099_RS15130 3088114..3088548 + 435 WP_102248537.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
C0099_RS15135 3088548..3089033 + 486 WP_102248199.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
C0099_RS15140 3089011..3089469 + 459 WP_123785285.1 hypothetical protein -
C0099_RS15145 3089466..3090179 + 714 WP_102248201.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13602.64 Da        Isoelectric Point: 6.2821

>T91714 WP_102248195.1 NZ_CP025682:c3085871-3085500 [Azoarcus pumilus]
MILVDTSVWIDHMRSTEAHLSELLNEGRVCMHPHVLGEIALGSLNHRAVVLEAMQNLPPAIVATDDEVFRFIDDHALFGL
GVGYTDAHLLAATKLSPGTRLWTRDRRLGSVTARLGIAYELPH

Download         Length: 372 bp

>T91714 NZ_CP025682:c3085871-3085500 [Azoarcus pumilus]
ATGATCCTGGTGGACACCTCGGTCTGGATCGACCACATGCGTAGCACCGAAGCACACTTGTCCGAACTTTTGAACGAAGG
ACGGGTGTGCATGCACCCGCATGTGTTGGGCGAGATCGCACTCGGCAGTCTCAACCATCGGGCAGTCGTGCTCGAGGCAA
TGCAGAATCTTCCGCCTGCGATCGTGGCCACCGACGACGAAGTCTTTCGCTTCATCGACGATCACGCCCTCTTCGGGCTG
GGCGTCGGCTATACCGATGCTCACCTGCTGGCAGCTACCAAGCTATCACCGGGTACCCGGCTCTGGACGCGCGATCGGCG
CCTCGGCAGCGTCACTGCCCGGCTCGGGATCGCTTACGAATTGCCCCACTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7268.38 Da        Isoelectric Point: 8.9168

>AT91714 WP_102248196.1 NZ_CP025682:c3086068-3085868 [Azoarcus pumilus]
MRTTLALDDELLAKAQALTGMAEKSALVKEALRALIQRESARRLALLGGSEPQLTDIPRRRTEHGE

Download         Length: 201 bp

>AT91714 NZ_CP025682:c3086068-3085868 [Azoarcus pumilus]
ATGCGCACCACGCTCGCGCTCGATGATGAACTTTTGGCCAAGGCCCAGGCGCTGACCGGCATGGCCGAAAAATCTGCCTT
GGTGAAGGAGGCGTTGCGAGCGCTCATCCAACGCGAAAGCGCCCGCCGGCTGGCCCTGCTGGGCGGCTCAGAACCACAGC
TGACCGACATCCCGCGGCGCCGGACGGAACACGGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References