Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2934966..2935558 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0099_RS14380 Protein ID WP_102248063.1
Coordinates 2934966..2935328 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0099_RS14385 Protein ID WP_102248064.1
Coordinates 2935337..2935558 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS14355 2930992..2932020 - 1029 WP_102245957.1 IS30 family transposase -
C0099_RS14360 2931989..2932453 - 465 WP_199797625.1 hypothetical protein -
C0099_RS14365 2932555..2933301 - 747 WP_102248060.1 DUF2971 domain-containing protein -
C0099_RS14370 2933389..2934246 - 858 WP_102248061.1 DUF2806 domain-containing protein -
C0099_RS14375 2934636..2934896 - 261 WP_102248062.1 DUF2442 domain-containing protein -
C0099_RS14380 2934966..2935328 - 363 WP_102248063.1 type II toxin-antitoxin system VapC family toxin Toxin
C0099_RS14385 2935337..2935558 - 222 WP_102248064.1 ribbon-helix-helix domain-containing protein Antitoxin
C0099_RS14390 2935751..2939452 - 3702 WP_102248065.1 methionine synthase -
C0099_RS14395 2939640..2940209 - 570 WP_102248066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13642.73 Da        Isoelectric Point: 6.9829

>T91711 WP_102248063.1 NZ_CP025682:c2935328-2934966 [Azoarcus pumilus]
MKALFDTNILIDYLNGVDAARREINRYEQCLISPITWMEVMVGADPGTDISVRAFLARFSQVPVTSEVAEQAVELRRRHR
LRLPDAIIWASARVEGALLVTRDIKDFRADAADVRVPYRV

Download         Length: 363 bp

>T91711 NZ_CP025682:c2935328-2934966 [Azoarcus pumilus]
ATGAAGGCGCTATTCGATACCAACATCCTGATCGACTACCTCAACGGCGTGGATGCCGCGCGCCGCGAGATCAATCGTTA
TGAGCAGTGTCTGATCAGCCCGATCACCTGGATGGAAGTCATGGTCGGAGCCGACCCGGGAACCGACATCTCCGTACGGG
CCTTCCTCGCCCGGTTCTCTCAAGTCCCGGTCACGTCTGAAGTCGCCGAGCAGGCCGTCGAACTGCGGCGCCGGCATCGC
CTGCGCCTGCCCGACGCCATAATCTGGGCGAGCGCTCGGGTCGAGGGCGCACTGCTCGTCACCCGCGATATCAAAGACTT
CCGCGCAGATGCGGCCGATGTCCGTGTGCCTTACCGCGTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8575.60 Da        Isoelectric Point: 4.8779

>AT91711 WP_102248064.1 NZ_CP025682:c2935558-2935337 [Azoarcus pumilus]
MRTIIDLPEDQYEALKSLAKREQASRAEVVRRALAEYLARRAPEAQDDAFGLWRDRAEDGLACQEKLRQEWDR

Download         Length: 222 bp

>AT91711 NZ_CP025682:c2935558-2935337 [Azoarcus pumilus]
ATGCGCACCATCATCGACCTGCCGGAAGACCAGTACGAAGCCTTGAAGTCCCTCGCTAAGCGCGAGCAGGCCTCACGTGC
CGAGGTGGTGCGCCGCGCACTGGCCGAGTATCTTGCGCGGCGTGCACCGGAGGCGCAGGACGACGCCTTCGGCCTGTGGC
GTGACCGCGCCGAGGATGGCCTTGCCTGTCAGGAGAAGCTACGGCAGGAGTGGGATCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References