Detailed information of TA system TA091706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1691362..1691961
• Replicon: chromosome
• Accession: NZ_CP025682
• Organism: Azoarcus pumilus strain SY39

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: C0099_RS08175
• Protein ID: WP_102246976.1
• Coordinates: 1691665..1691961 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C0099_RS08170
• Protein ID: WP_102246975.1
• Coordinates: 1691362..1691661 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0099_RS08135	1687080..1687478	-	399	WP_102246968.1	MAPEG family protein	-
C0099_RS08140	1687568..1688533	-	966	WP_102246969.1	putative zinc-binding metallopeptidase	-
C0099_RS08145	1688648..1689514	-	867	WP_102246970.1	sensor domain-containing diguanylate cyclase	-
C0099_RS08150	1689608..1689988	-	381	WP_102246971.1	type II toxin-antitoxin system VapC family toxin	-
C0099_RS08155	1689985..1690191	-	207	WP_102246972.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
C0099_RS08160	1690329..1690838	+	510	WP_164084889.1	cupin domain-containing protein	-
C0099_RS08165	1690953..1691300	-	348	WP_102246974.1	hypothetical protein	-
C0099_RS08170	1691362..1691661	-	300	WP_102246975.1	putative addiction module antidote protein	Antitoxin
C0099_RS08175	1691665..1691961	-	297	WP_102246976.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C0099_RS08180	1692266..1694008	+	1743	WP_102246977.1	ATP-binding cassette domain-containing protein	-
C0099_RS08185	1694022..1695083	-	1062	WP_102246978.1	HlyD family efflux transporter periplasmic adaptor subunit	-
C0099_RS08190	1695086..1696345	-	1260	WP_102246979.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11074.86 Da
• Isoelectric Point: 10.6980

>T91706 WP_102246976.1 NZ_CP025682:c1691961-1691665 [Azoarcus pumilus]
MVEVIKSTAFEEWFAQLRDRHARMRIVARIRRLSLGNPGDVKPVGEGVSEMRIDHGPGYRVYFLRRGPLVVVLLCGGDKR
TQGRDIADAKAIAAQWKD

Nucleotide

• Length: 297 bp

>T91706 NZ_CP025682:c1691961-1691665 [Azoarcus pumilus]
ATGGTCGAGGTCATCAAGAGTACGGCCTTCGAAGAATGGTTCGCGCAATTGCGTGACCGTCACGCGCGTATGCGCATCGT
TGCGCGTATCCGACGCTTGAGTCTGGGGAATCCGGGCGATGTGAAGCCGGTGGGCGAGGGCGTTTCGGAGATGCGCATCG
ATCATGGTCCCGGCTACCGGGTATATTTTCTGCGGCGAGGTCCGCTGGTGGTGGTTCTTCTTTGCGGTGGTGACAAGCGC
ACGCAAGGGCGGGACATCGCCGACGCCAAGGCCATTGCCGCGCAATGGAAGGACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10949.42 Da
• Isoelectric Point: 4.6582

>AT91706 WP_102246975.1 NZ_CP025682:c1691661-1691362 [Azoarcus pumilus]
MNETAETFSRWDAADYLRTEEDMRLYLEACLDDGDPALIAAALGDIARARNMSELARQTGLSREGLYKALSGDGNPTFAT
IMKVARALGLRLRLEPIRS

Nucleotide

• Length: 300 bp

>AT91706 NZ_CP025682:c1691661-1691362 [Azoarcus pumilus]
ATGAACGAGACCGCCGAGACCTTCAGCCGCTGGGACGCCGCGGATTATCTGCGCACCGAAGAAGACATGCGCCTGTACCT
GGAAGCGTGTCTGGATGACGGCGATCCGGCGCTGATCGCGGCTGCGCTGGGGGACATCGCCCGCGCACGCAACATGAGCG
AACTGGCGCGCCAGACGGGGCTCTCGCGAGAAGGGCTTTACAAGGCGCTTTCGGGCGACGGAAACCCGACGTTCGCGACC
ATCATGAAAGTCGCCAGAGCGCTGGGGTTGCGGTTGCGGTTGGAGCCGATACGTTCCTGA