Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 230597..231255 | Replicon | chromosome |
Accession | NZ_CP025682 | ||
Organism | Azoarcus pumilus strain SY39 |
Toxin (Protein)
Gene name | VapC1 | Uniprot ID | - |
Locus tag | C0099_RS01140 | Protein ID | WP_102245733.1 |
Coordinates | 230597..231004 (-) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | VapB1 | Uniprot ID | - |
Locus tag | C0099_RS01145 | Protein ID | WP_102245734.1 |
Coordinates | 231001..231255 (-) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C0099_RS01120 | 226402..227115 | + | 714 | WP_102245729.1 | M15 family metallopeptidase | - |
C0099_RS01125 | 227124..227552 | + | 429 | WP_164084849.1 | DUF3293 domain-containing protein | - |
C0099_RS01130 | 227569..228534 | - | 966 | WP_102245731.1 | SDR family oxidoreductase | - |
C0099_RS01135 | 228712..230595 | + | 1884 | WP_102245732.1 | ABC transporter ATP-binding protein/permease | - |
C0099_RS01140 | 230597..231004 | - | 408 | WP_102245733.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
C0099_RS01145 | 231001..231255 | - | 255 | WP_102245734.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
C0099_RS01150 | 231441..232694 | + | 1254 | WP_102245735.1 | urea ABC transporter substrate-binding protein | - |
C0099_RS01155 | 232773..234392 | + | 1620 | WP_102245736.1 | urea ABC transporter permease subunit UrtB | - |
C0099_RS01160 | 234548..235756 | + | 1209 | WP_102245737.1 | urea ABC transporter permease subunit UrtC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15052.32 Da Isoelectric Point: 6.8619
>T91703 WP_102245733.1 NZ_CP025682:c231004-230597 [Azoarcus pumilus]
VIYLLDTNILIYLIRNRPPQVAERVDALPEGDALAMSFITYAELLKGAERSTRKPEVLGRLTALTRQVPVLYPSKPDICH
HYAAQFSRLKAAGTPIGANDLWIACHALAEGATLVTHNTREFDRIEGLRVEDWAT
VIYLLDTNILIYLIRNRPPQVAERVDALPEGDALAMSFITYAELLKGAERSTRKPEVLGRLTALTRQVPVLYPSKPDICH
HYAAQFSRLKAAGTPIGANDLWIACHALAEGATLVTHNTREFDRIEGLRVEDWAT
Download Length: 408 bp
>T91703 NZ_CP025682:c231004-230597 [Azoarcus pumilus]
GTGATCTACCTGCTCGACACCAACATCCTGATCTACCTGATCAGGAACCGGCCACCGCAGGTCGCCGAGCGGGTGGACGC
ACTGCCGGAGGGCGATGCGCTGGCGATGTCCTTCATCACCTATGCGGAACTGCTCAAGGGGGCCGAGCGCAGCACGCGCA
AGCCGGAAGTGCTGGGCCGGCTGACCGCGCTCACGCGACAGGTGCCGGTGCTGTATCCGTCGAAACCCGACATCTGCCAT
CACTACGCCGCACAGTTCTCCCGCCTGAAGGCGGCGGGAACGCCGATCGGCGCCAACGACCTGTGGATCGCATGCCATGC
ACTGGCCGAAGGCGCGACGCTGGTCACGCACAACACGCGCGAGTTCGACCGCATCGAGGGGTTGAGGGTCGAAGACTGGG
CGACGTGA
GTGATCTACCTGCTCGACACCAACATCCTGATCTACCTGATCAGGAACCGGCCACCGCAGGTCGCCGAGCGGGTGGACGC
ACTGCCGGAGGGCGATGCGCTGGCGATGTCCTTCATCACCTATGCGGAACTGCTCAAGGGGGCCGAGCGCAGCACGCGCA
AGCCGGAAGTGCTGGGCCGGCTGACCGCGCTCACGCGACAGGTGCCGGTGCTGTATCCGTCGAAACCCGACATCTGCCAT
CACTACGCCGCACAGTTCTCCCGCCTGAAGGCGGCGGGAACGCCGATCGGCGCCAACGACCTGTGGATCGCATGCCATGC
ACTGGCCGAAGGCGCGACGCTGGTCACGCACAACACGCGCGAGTTCGACCGCATCGAGGGGTTGAGGGTCGAAGACTGGG
CGACGTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9322.46 Da Isoelectric Point: 4.6135
>AT91703 WP_102245734.1 NZ_CP025682:c231255-231001 [Azoarcus pumilus]
MNELTTRVFANGNSQAVRIPAELRLDTDRVRIHRNADGDLVIHPLPAQRGKALLAALEGFDDEFVAALEEDRAAAQPMQD
RETL
MNELTTRVFANGNSQAVRIPAELRLDTDRVRIHRNADGDLVIHPLPAQRGKALLAALEGFDDEFVAALEEDRAAAQPMQD
RETL
Download Length: 255 bp
>AT91703 NZ_CP025682:c231255-231001 [Azoarcus pumilus]
ATGAATGAACTAACGACACGGGTCTTCGCCAACGGCAACAGCCAGGCGGTACGCATCCCCGCGGAACTGCGGCTGGACAC
CGACCGCGTGCGCATTCATCGCAATGCCGACGGGGATCTCGTCATCCACCCGCTGCCGGCGCAGCGCGGCAAGGCCTTGC
TCGCCGCACTGGAAGGCTTCGACGACGAATTCGTCGCCGCGCTGGAGGAGGATCGCGCTGCAGCGCAGCCGATGCAGGAC
CGCGAAACGCTGTGA
ATGAATGAACTAACGACACGGGTCTTCGCCAACGGCAACAGCCAGGCGGTACGCATCCCCGCGGAACTGCGGCTGGACAC
CGACCGCGTGCGCATTCATCGCAATGCCGACGGGGATCTCGTCATCCACCCGCTGCCGGCGCAGCGCGGCAAGGCCTTGC
TCGCCGCACTGGAAGGCTTCGACGACGAATTCGTCGCCGCGCTGGAGGAGGATCGCGCTGCAGCGCAGCCGATGCAGGAC
CGCGAAACGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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