Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 230597..231255 Replicon chromosome
Accession NZ_CP025682
Organism Azoarcus pumilus strain SY39

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag C0099_RS01140 Protein ID WP_102245733.1
Coordinates 230597..231004 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag C0099_RS01145 Protein ID WP_102245734.1
Coordinates 231001..231255 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0099_RS01120 226402..227115 + 714 WP_102245729.1 M15 family metallopeptidase -
C0099_RS01125 227124..227552 + 429 WP_164084849.1 DUF3293 domain-containing protein -
C0099_RS01130 227569..228534 - 966 WP_102245731.1 SDR family oxidoreductase -
C0099_RS01135 228712..230595 + 1884 WP_102245732.1 ABC transporter ATP-binding protein/permease -
C0099_RS01140 230597..231004 - 408 WP_102245733.1 type II toxin-antitoxin system VapC family toxin Toxin
C0099_RS01145 231001..231255 - 255 WP_102245734.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C0099_RS01150 231441..232694 + 1254 WP_102245735.1 urea ABC transporter substrate-binding protein -
C0099_RS01155 232773..234392 + 1620 WP_102245736.1 urea ABC transporter permease subunit UrtB -
C0099_RS01160 234548..235756 + 1209 WP_102245737.1 urea ABC transporter permease subunit UrtC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(11-42)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15052.32 Da        Isoelectric Point: 6.8619

>T91703 WP_102245733.1 NZ_CP025682:c231004-230597 [Azoarcus pumilus]
VIYLLDTNILIYLIRNRPPQVAERVDALPEGDALAMSFITYAELLKGAERSTRKPEVLGRLTALTRQVPVLYPSKPDICH
HYAAQFSRLKAAGTPIGANDLWIACHALAEGATLVTHNTREFDRIEGLRVEDWAT

Download         Length: 408 bp

>T91703 NZ_CP025682:c231004-230597 [Azoarcus pumilus]
GTGATCTACCTGCTCGACACCAACATCCTGATCTACCTGATCAGGAACCGGCCACCGCAGGTCGCCGAGCGGGTGGACGC
ACTGCCGGAGGGCGATGCGCTGGCGATGTCCTTCATCACCTATGCGGAACTGCTCAAGGGGGCCGAGCGCAGCACGCGCA
AGCCGGAAGTGCTGGGCCGGCTGACCGCGCTCACGCGACAGGTGCCGGTGCTGTATCCGTCGAAACCCGACATCTGCCAT
CACTACGCCGCACAGTTCTCCCGCCTGAAGGCGGCGGGAACGCCGATCGGCGCCAACGACCTGTGGATCGCATGCCATGC
ACTGGCCGAAGGCGCGACGCTGGTCACGCACAACACGCGCGAGTTCGACCGCATCGAGGGGTTGAGGGTCGAAGACTGGG
CGACGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9322.46 Da        Isoelectric Point: 4.6135

>AT91703 WP_102245734.1 NZ_CP025682:c231255-231001 [Azoarcus pumilus]
MNELTTRVFANGNSQAVRIPAELRLDTDRVRIHRNADGDLVIHPLPAQRGKALLAALEGFDDEFVAALEEDRAAAQPMQD
RETL

Download         Length: 255 bp

>AT91703 NZ_CP025682:c231255-231001 [Azoarcus pumilus]
ATGAATGAACTAACGACACGGGTCTTCGCCAACGGCAACAGCCAGGCGGTACGCATCCCCGCGGAACTGCGGCTGGACAC
CGACCGCGTGCGCATTCATCGCAATGCCGACGGGGATCTCGTCATCCACCCGCTGCCGGCGCAGCGCGGCAAGGCCTTGC
TCGCCGCACTGGAAGGCTTCGACGACGAATTCGTCGCCGCGCTGGAGGAGGATCGCGCTGCAGCGCAGCCGATGCAGGAC
CGCGAAACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References