Detailed information of TA system TA091699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 39236..39758
• Replicon: plasmid pEA-3
• Accession: NZ_CP025679
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YLU1
• Locus tag: C0R48_RS26790
• Protein ID: WP_000638823.1
• Coordinates: 39477..39758 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y7J1
• Locus tag: C0R48_RS26785
• Protein ID: WP_000121741.1
• Coordinates: 39236..39487 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS27425	34305..34475	+	171	WP_000550720.1	hypothetical protein	-
C0R48_RS26740	34486..34698	+	213	WP_039022940.1	hypothetical protein	-
C0R48_RS26750	34969..35271	+	303	WP_001360345.1	hypothetical protein	-
C0R48_RS26755	35268..35525	+	258	WP_000739144.1	hypothetical protein	-
C0R48_RS26760	35529..36524	+	996	WP_001028541.1	type IV secretion system protein	-
C0R48_RS26765	36530..37174	+	645	WP_001310442.1	conjugal transfer protein TrbJ	-
C0R48_RS26770	37183..37407	+	225	WP_000713561.1	EexN family lipoprotein	-
C0R48_RS26775	37621..38453	-	833	Protein_48	DNA primase	-
C0R48_RS26780	38501..39136	+	636	WP_015059536.1	hypothetical protein	-
C0R48_RS26785	39236..39487	+	252	WP_000121741.1	hypothetical protein	Antitoxin
C0R48_RS26790	39477..39758	+	282	WP_000638823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C0R48_RS26795	39826..40125	+	300	WP_000835764.1	IncN plasmid KikA protein	-
C0R48_RS26800	40128..41363	+	1236	WP_015059538.1	TcpQ domain-containing protein	-
C0R48_RS26805	41369..41806	+	438	WP_000539665.1	type IV pilus biogenesis protein PilM	-
C0R48_RS26810	41925..42323	+	399	WP_001153665.1	hypothetical protein	-
C0R48_RS26815	42344..42928	+	585	WP_001177113.1	lytic transglycosylase domain-containing protein	-
C0R48_RS26820	43030..43218	+	189	WP_050567133.1	hypothetical protein	-
C0R48_RS26825	43289..43609	+	321	WP_000362080.1	VirB3 family type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	mcr-1.1	-	1..68747	68747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10945.79 Da
• Isoelectric Point: 10.4997

>T91699 WP_000638823.1 NZ_CP025679:39477-39758 [Escherichia albertii]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR

Nucleotide

• Length: 282 bp

>T91699 NZ_CP025679:39477-39758 [Escherichia albertii]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9223.38 Da
• Isoelectric Point: 3.9823

>AT91699 WP_000121741.1 NZ_CP025679:39236-39487 [Escherichia albertii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL

Nucleotide

• Length: 252 bp

>AT91699 NZ_CP025679:39236-39487 [Escherichia albertii]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Structures

Toxin

• AlphaFold DB: U9YLU1

Antitoxin

• AlphaFold DB: U9Y7J1