Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 39438..39985 Replicon plasmid pEA-2
Accession NZ_CP025678
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag C0R48_RS26410 Protein ID WP_059274487.1
Coordinates 39704..39985 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag C0R48_RS26405 Protein ID WP_021499564.1
Coordinates 39438..39707 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS26345 34676..34888 + 213 WP_032197545.1 ANR family transcriptional regulator -
C0R48_RS27400 35122..35223 + 102 Protein_40 endonuclease -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
C0R48_RS26360 35568..35717 + 150 WP_001312851.1 type I toxin-antitoxin system Hok family toxin -
C0R48_RS26365 36039..36341 + 303 WP_076751484.1 DUF1778 domain-containing protein -
C0R48_RS26370 36332..36814 + 483 WP_072250165.1 GNAT family N-acetyltransferase -
C0R48_RS26375 37131..37388 + 258 WP_059274488.1 replication regulatory protein RepA -
C0R48_RS26385 37621..37695 + 75 WP_001370046.1 RepA leader peptide Tap -
C0R48_RS26390 37688..38521 + 834 Protein_46 incFII family plasmid replication initiator RepA -
C0R48_RS26405 39438..39707 + 270 WP_021499564.1 hypothetical protein Antitoxin
C0R48_RS26410 39704..39985 + 282 WP_059274487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0R48_RS27205 40316..40492 + 177 WP_157941416.1 hypothetical protein -
C0R48_RS26420 40725..41204 - 480 WP_059274486.1 heme-binding protein -
C0R48_RS26425 41285..41968 + 684 Protein_51 IS1 family transposase -
C0R48_RS26430 42725..43886 - 1162 Protein_52 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - espL2 / espL2 / espL2 / vat 1..57110 57110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10907.59 Da        Isoelectric Point: 8.4615

>T91696 WP_059274487.1 NZ_CP025678:39704-39985 [Escherichia albertii]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRILHTAQKWP

Download         Length: 282 bp

>T91696 NZ_CP025678:39704-39985 [Escherichia albertii]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATCCTGCGCATATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.46 Da        Isoelectric Point: 8.8735

>AT91696 WP_021499564.1 NZ_CP025678:39438-39707 [Escherichia albertii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGRGDVLPHDMVESSAAAWRD
EISRKVDGK

Download         Length: 270 bp

>AT91696 NZ_CP025678:39438-39707 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGACAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATAAGCAGGAAGGTTGACGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References