Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 36039..36814 Replicon plasmid pEA-2
Accession NZ_CP025678
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag C0R48_RS26370 Protein ID WP_072250165.1
Coordinates 36332..36814 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag C0R48_RS26365 Protein ID WP_076751484.1
Coordinates 36039..36341 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS26315 31354..31665 + 312 WP_000012106.1 type IV conjugative transfer system protein TraL -
C0R48_RS26320 31687..31943 + 257 Protein_34 type IV conjugative transfer system protein TraE -
C0R48_RS26325 31937..32131 + 195 Protein_35 conjugal transfer protein TraC -
C0R48_RS26330 32133..33756 + 1624 Protein_36 AAA family ATPase -
C0R48_RS26335 33758..33925 + 168 Protein_37 conjugal transfer protein -
C0R48_RS26340 33980..34540 + 561 WP_001567328.1 fertility inhibition protein FinO -
C0R48_RS26345 34676..34888 + 213 WP_032197545.1 ANR family transcriptional regulator -
C0R48_RS27400 35122..35223 + 102 Protein_40 endonuclease -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
- 35464..35523 - 60 NuclAT_0 - -
C0R48_RS26360 35568..35717 + 150 WP_001312851.1 type I toxin-antitoxin system Hok family toxin -
C0R48_RS26365 36039..36341 + 303 WP_076751484.1 DUF1778 domain-containing protein Antitoxin
C0R48_RS26370 36332..36814 + 483 WP_072250165.1 GNAT family N-acetyltransferase Toxin
C0R48_RS26375 37131..37388 + 258 WP_059274488.1 replication regulatory protein RepA -
C0R48_RS26385 37621..37695 + 75 WP_001370046.1 RepA leader peptide Tap -
C0R48_RS26390 37688..38521 + 834 Protein_46 incFII family plasmid replication initiator RepA -
C0R48_RS26405 39438..39707 + 270 WP_021499564.1 hypothetical protein -
C0R48_RS26410 39704..39985 + 282 WP_059274487.1 type II toxin-antitoxin system RelE/ParE family toxin -
C0R48_RS27205 40316..40492 + 177 WP_157941416.1 hypothetical protein -
C0R48_RS26420 40725..41204 - 480 WP_059274486.1 heme-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - espL2 / espL2 / espL2 / vat 1..57110 57110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(30-149)

Antitoxin

Vibrio phage ICP1, Orf50

(19-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17645.39 Da        Isoelectric Point: 7.1036

>T91695 WP_072250165.1 NZ_CP025678:36332-36814 [Escherichia albertii]
MEINVTAPALLTDEHILQPFDCGNEVLSNWLHGRAMKNQMLNASRTFVICLEGTLRVVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCSQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV

Download         Length: 483 bp

>T91695 NZ_CP025678:36332-36814 [Escherichia albertii]
ATGGAAATAAATGTCACCGCACCGGCATTACTGACGGATGAGCATATACTTCAGCCATTTGATTGTGGGAATGAAGTGTT
AAGTAACTGGTTACATGGTCGCGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTCATTTGCCTGGAGGGTA
CTTTACGTGTTGTGGGATACTACTCATTAGCTACTGGCTCCGTCACTCATGCCGAACTTGGGCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTTCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTTCTCAGGGGCATGGTTTTGGTAAATG
GCTGCTGAGTGATGCCATTCATCGGGTTGTCAATCTGGCTGATCAGGTTGGTATTAAGGCTGTTATGGTTCATGCAATTG
ATGATGATGCCAGAGCGTTTTATGAGCGTTTTGGTTTTGTCCAGTCAGTTGTGGCACCAAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11587.22 Da        Isoelectric Point: 4.4569

>AT91695 WP_076751484.1 NZ_CP025678:36039-36341 [Escherichia albertii]
MEVVMPTTASIRKTPRENQINIRATDEERAVIDYAASLVNKNRTDFIIELAYQEAKNIILDQRLFVLDDECYDSFITQLE
APVLNAEGRERLMAVKPEWK

Download         Length: 303 bp

>AT91695 NZ_CP025678:36039-36341 [Escherichia albertii]
ATGGAGGTTGTTATGCCTACTACTGCAAGCATCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACGGATGA
GGAACGAGCTGTTATTGATTATGCCGCTAGCCTAGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATCATCCTGGATCAACGTTTATTTGTGCTGGATGATGAATGTTATGATTCATTTATTACGCAACTTGAA
GCTCCTGTGCTGAATGCTGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References