Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 13212..13747 Replicon plasmid pEA-2
Accession NZ_CP025678
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4VX23
Locus tag C0R48_RS26210 Protein ID WP_054412868.1
Coordinates 13460..13747 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K4VWT1
Locus tag C0R48_RS26205 Protein ID WP_054412870.1
Coordinates 13212..13463 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS26185 8525..9502 - 978 WP_054412876.1 RepB family plasmid replication initiator protein -
C0R48_RS26195 10595..11761 + 1167 WP_054412873.1 plasmid-partitioning protein SopA -
C0R48_RS26200 11761..12732 + 972 WP_054412871.1 ParB/RepB/Spo0J family plasmid partition protein -
C0R48_RS26205 13212..13463 + 252 WP_054412870.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C0R48_RS26210 13460..13747 + 288 WP_054412868.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0R48_RS27195 13883..14189 + 307 Protein_13 helix-turn-helix domain-containing protein -
C0R48_RS27200 14565..14795 + 231 WP_158649826.1 hypothetical protein -
C0R48_RS26220 15094..15807 - 714 WP_054412866.1 molecular chaperone -
C0R48_RS26225 15804..17132 - 1329 WP_059274462.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - espL2 / espL2 / espL2 / vat 1..57110 57110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11149.20 Da        Isoelectric Point: 10.5832

>T91690 WP_054412868.1 NZ_CP025678:13460-13747 [Escherichia albertii]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRELKSCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T91690 NZ_CP025678:13460-13747 [Escherichia albertii]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAGCAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGTGAACTAAAAAGTTGCTACAAAATCA
AACTTCGTGCATCGGGTTTTCGTCTGGTCTATCAGGTTATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTTGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9209.44 Da        Isoelectric Point: 4.0780

>AT91690 WP_054412870.1 NZ_CP025678:13212-13463 [Escherichia albertii]
MPNIILSDTSASVSELKKNPMATVGAGDGYPVAILNRNQPVFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT91690 NZ_CP025678:13212-13463 [Escherichia albertii]
ATGCCTAATATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAACCCAATGGCAACAGTCGGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGAAACCAGCCGGTATTCTACTGTGTGCCTGCGGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGATCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAACCAGCCACTGCATGATGTGGACTTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4VX23

Antitoxin

Source ID Structure
AlphaFold DB A0A0K4VWT1

References