Detailed information of TA system TA091679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4430485..4431529
• Replicon: chromosome
• Accession: NZ_CP025676
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A8I0CFN6
• Locus tag: C0R48_RS22895
• Protein ID: WP_059274466.1
• Coordinates: 4430485..4431033 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A839B6W4
• Locus tag: C0R48_RS22900
• Protein ID: WP_000287252.1
• Coordinates: 4431056..4431529 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS22845	4425786..4426610	+	825	WP_000081287.1	DUF2303 family protein	-
C0R48_RS22850	4426738..4427274	+	537	WP_000008232.1	5'-deoxynucleotidase	-
C0R48_RS22855	4427265..4427627	+	363	WP_001242733.1	phage protein	-
C0R48_RS22860	4427624..4427827	+	204	WP_000111288.1	hypothetical protein	-
C0R48_RS22865	4427820..4428059	+	240	WP_000476212.1	hypothetical protein	-
C0R48_RS22870	4428056..4428610	+	555	WP_040092683.1	ead/Ea22-like family protein	-
C0R48_RS22875	4428612..4428803	+	192	WP_001014290.1	hypothetical protein	-
C0R48_RS22880	4428806..4429573	+	768	WP_058100692.1	hypothetical protein	-
C0R48_RS22885	4429573..4430145	+	573	WP_001061339.1	3'-5' exoribonuclease	-
C0R48_RS22890	4430182..4430451	+	270	WP_001093912.1	pyocin activator PrtN family protein	-
C0R48_RS22895	4430485..4431033	-	549	WP_059274466.1	hypothetical protein	Toxin
C0R48_RS22900	4431056..4431529	-	474	WP_000287252.1	SocA family protein	Antitoxin
C0R48_RS22905	4432052..4432567	+	516	WP_002460756.1	zinc uptake transcriptional repressor Zur	-
C0R48_RS22910	4432608..4432817	-	210	WP_001030604.1	CsbD family protein	-
C0R48_RS22915	4432933..4434258	-	1326	WP_000874972.1	MATE family efflux transporter DinF	-
C0R48_RS22920	4434333..4434941	-	609	WP_000646078.1	transcriptional repressor LexA	-
C0R48_RS22925	4435055..4435423	-	369	WP_000002912.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4383668..4435423	51755

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 20052.43 Da
• Isoelectric Point: 4.4481

>T91679 WP_059274466.1 NZ_CP025676:c4431033-4430485 [Escherichia albertii]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Nucleotide

• Length: 549 bp

>T91679 NZ_CP025676:c4431033-4430485 [Escherichia albertii]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17298.80 Da
• Isoelectric Point: 8.4143

>AT91679 WP_000287252.1 NZ_CP025676:c4431529-4431056 [Escherichia albertii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT91679 NZ_CP025676:c4431529-4431056 [Escherichia albertii]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A839B6W4