Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3540693..3541311 Replicon chromosome
Accession NZ_CP025676
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag C0R48_RS18355 Protein ID WP_001280991.1
Coordinates 3541093..3541311 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag C0R48_RS18350 Protein ID WP_000344798.1
Coordinates 3540693..3541067 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS18340 3535773..3536966 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C0R48_RS18345 3536989..3540138 + 3150 WP_102204125.1 efflux RND transporter permease AcrB -
C0R48_RS18350 3540693..3541067 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
C0R48_RS18355 3541093..3541311 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
C0R48_RS18360 3541488..3542045 + 558 WP_000093562.1 maltose O-acetyltransferase -
C0R48_RS18365 3542153..3542623 + 471 WP_000136188.1 YlaC family protein -
C0R48_RS18370 3542787..3544337 + 1551 WP_001260378.1 EAL domain-containing protein -
C0R48_RS18375 3544375..3544728 - 354 WP_059250357.1 DUF1428 family protein -
C0R48_RS18385 3545109..3545420 + 312 WP_000409915.1 MGMT family protein -
C0R48_RS18390 3545450..3546022 - 573 WP_000779847.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T91672 WP_001280991.1 NZ_CP025676:3541093-3541311 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T91672 NZ_CP025676:3541093-3541311 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT91672 WP_000344798.1 NZ_CP025676:3540693-3541067 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT91672 NZ_CP025676:3540693-3541067 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References