Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 893045..893696 Replicon chromosome
Accession NZ_CP025676
Organism Escherichia albertii strain ChinaSP140150

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag C0R48_RS04560 Protein ID WP_000244763.1
Coordinates 893292..893696 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C0R48_RS04555 Protein ID WP_000354046.1
Coordinates 893045..893311 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0R48_RS04530 888756..890189 - 1434 WP_059235410.1 6-phospho-beta-glucosidase BglA -
C0R48_RS04535 890234..890545 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
C0R48_RS04540 890713..891372 + 660 WP_000250281.1 hemolysin III family protein -
C0R48_RS04545 891813..892793 - 981 WP_059235393.1 tRNA-modifying protein YgfZ -
C0R48_RS04550 892825..893055 + 231 WP_000181267.1 hypothetical protein -
C0R48_RS04555 893045..893311 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C0R48_RS04560 893292..893696 + 405 WP_000244763.1 protein YgfX Toxin
C0R48_RS04565 893735..894256 - 522 WP_059235395.1 flavodoxin FldB -
C0R48_RS04570 894368..895264 + 897 WP_059228147.1 site-specific tyrosine recombinase XerD -
C0R48_RS04575 895289..895999 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C0R48_RS04580 896005..897738 + 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T91660 WP_000244763.1 NZ_CP025676:893292-893696 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T91660 NZ_CP025676:893292-893696 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT91660 WP_000354046.1 NZ_CP025676:893045-893311 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT91660 NZ_CP025676:893045-893311 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References