Detailed information of TA system TA091658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 306195..306995
• Replicon: chromosome
• Accession: NZ_CP025676
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: A0A8H9C5V7
• Locus tag: C0R48_RS01480
• Protein ID: WP_000342455.1
• Coordinates: 306468..306995 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: B1EHP0
• Locus tag: C0R48_RS01475
• Protein ID: WP_001277106.1
• Coordinates: 306195..306461 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS01455	301791..302849	+	1059	WP_001042000.1	permease-like cell division protein FtsX	-
C0R48_RS01460	303094..303948	+	855	WP_000130217.1	RNA polymerase sigma factor RpoH	-
C0R48_RS01465	304145..304654	+	510	WP_059235675.1	hypothetical protein	-
C0R48_RS01470	304942..306045	+	1104	WP_010319184.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
C0R48_RS01475	306195..306461	+	267	WP_001277106.1	DUF1778 domain-containing protein	Antitoxin
C0R48_RS01480	306468..306995	+	528	WP_000342455.1	GNAT family N-acetyltransferase	Toxin
C0R48_RS01485	306992..307375	-	384	WP_059235673.1	aspartate 1-decarboxylase autocleavage activator PanM	-
C0R48_RS01490	307799..308908	+	1110	WP_102203922.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
C0R48_RS01495	308956..309882	+	927	WP_001295111.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
C0R48_RS01500	309879..311156	+	1278	WP_044709902.1	branched chain amino acid ABC transporter permease LivM	-
C0R48_RS01505	311153..311920	+	768	WP_059274779.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (90-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19607.47 Da
• Isoelectric Point: 6.6343

>T91658 WP_000342455.1 NZ_CP025676:306468-306995 [Escherichia albertii]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T91658 NZ_CP025676:306468-306995 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9942.37 Da
• Isoelectric Point: 10.0863

>AT91658 WP_001277106.1 NZ_CP025676:306195-306461 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT91658 NZ_CP025676:306195-306461 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z8E004