Detailed information of TA system TA091655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 152361..152973
• Replicon: chromosome
• Accession: NZ_CP025676
• Organism: Escherichia albertii strain ChinaSP140150

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C0R48_RS00710
• Protein ID: WP_059274867.1
• Coordinates: 152361..152546 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C0R48_RS00715
• Protein ID: WP_059235556.1
• Coordinates: 152563..152973 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0R48_RS00690	147825..149120	+	1296	WP_059235552.1	Fic family protein	-
C0R48_RS00695	149228..150766	+	1539	WP_059274866.1	aldehyde dehydrogenase AldB	-
C0R48_RS00700	150807..151886	-	1080	WP_025238097.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
C0R48_RS00710	152361..152546	+	186	WP_059274867.1	type II toxin-antitoxin system HicA family toxin	Toxin
C0R48_RS00715	152563..152973	+	411	WP_059235556.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C0R48_RS00720	153045..155009	-	1965	WP_102203916.1	glycoside hydrolase family 127 protein	-
C0R48_RS00725	155020..156420	-	1401	WP_025238099.1	MFS transporter	-
C0R48_RS00730	156646..157461	+	816	WP_059242247.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6816.93 Da
• Isoelectric Point: 11.7053

>T91655 WP_059274867.1 NZ_CP025676:152361-152546 [Escherichia albertii]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHLGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T91655 NZ_CP025676:152361-152546 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCTGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15193.10 Da
• Isoelectric Point: 4.5486

>AT91655 WP_059235556.1 NZ_CP025676:152563-152973 [Escherichia albertii]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQVEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT91655 NZ_CP025676:152563-152973 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA