Detailed information of TA system TA091627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1781..2328
• Replicon: plasmid pBOKZ_020007
• Accession: NZ_CP025625
• Organism: Escherichia coli strain SCEC020007

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: C0634_RS00025
• Protein ID: WP_025750222.1
• Coordinates: 2047..2328 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: K4JYR0
• Locus tag: C0634_RS00020
• Protein ID: WP_000079928.1
• Coordinates: 1781..2050 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0634_RS25975	1..873	+	873	WP_000729438.1	incFII family plasmid replication initiator RepA	-
C0634_RS26370	1568..1726	+	159	WP_032151498.1	hypothetical protein	-
C0634_RS00020	1781..2050	+	270	WP_000079928.1	hypothetical protein	Antitoxin
C0634_RS00025	2047..2328	+	282	WP_025750222.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C0634_RS00035	2842..3459	-	618	WP_025750220.1	hypothetical protein	-
C0634_RS00040	3768..4465	-	698	Protein_5	IS1 family transposase	-
C0634_RS00055	4699..6018	-	1320	WP_160470889.1	cation:dicarboxylase symporter family transporter	-
C0634_RS00060	6230..6927	+	698	Protein_7	IS1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..84952	84952

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.53 Da
• Isoelectric Point: 8.4615

>T91627 WP_025750222.1 NZ_CP025625:2047-2328 [Escherichia coli]
MIEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Nucleotide

• Length: 282 bp

>T91627 NZ_CP025625:2047-2328 [Escherichia coli]
ATGATAGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCGATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTACAAAGGTCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGTAAAGTG
TATATTTTGCGCGTGTTGCATACAGCACAGAAATGGCCATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10175.50 Da
• Isoelectric Point: 7.3210

>AT91627 WP_000079928.1 NZ_CP025625:1781-2050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT91627 NZ_CP025625:1781-2050 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCAGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGCGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5W2J4D0