Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6298328..6298967 Replicon chromosome
Accession NZ_CP025624
Organism Pseudomonas sp. NC02

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N7Y7G6
Locus tag C0058_RS29685 Protein ID WP_003211022.1
Coordinates 6298785..6298967 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2N7Y8H9
Locus tag C0058_RS29680 Protein ID WP_003211020.1
Coordinates 6298328..6298729 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0058_RS29655 6293657..6294544 + 888 WP_102370034.1 TIR domain-containing protein -
C0058_RS29660 6294666..6295109 - 444 WP_102370035.1 TIR domain-containing protein -
C0058_RS29665 6295121..6296551 - 1431 WP_102370309.1 SIR2 family protein -
C0058_RS29670 6296583..6297077 - 495 WP_102370036.1 toll/interleukin-1 receptor domain-containing protein -
C0058_RS29675 6297726..6298238 + 513 WP_008434401.1 cupin domain-containing protein -
C0058_RS29680 6298328..6298729 - 402 WP_003211020.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C0058_RS29685 6298785..6298967 - 183 WP_003211022.1 type II toxin-antitoxin system HicA family toxin Toxin
C0058_RS29690 6299153..6300406 - 1254 WP_102370037.1 amidase -
C0058_RS29695 6300417..6300842 - 426 WP_003211024.1 VOC family protein -
C0058_RS29700 6300956..6301822 + 867 WP_003211026.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 6277454..6298967 21513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6617.70 Da        Isoelectric Point: 10.9062

>T91626 WP_003211022.1 NZ_CP025624:c6298967-6298785 [Pseudomonas sp. NC02]
MRSREVIDLLMADGWFEVAAKGSHHQFKHSTKPGRVTVPHPKSEIAKGTLHSILKSAGLK

Download         Length: 183 bp

>T91626 NZ_CP025624:c6298967-6298785 [Pseudomonas sp. NC02]
ATGAGAAGCAGAGAGGTAATTGACTTGCTGATGGCGGATGGATGGTTTGAGGTGGCGGCGAAAGGCAGTCACCATCAATT
CAAGCACTCAACCAAGCCCGGCCGGGTGACGGTTCCTCATCCTAAATCAGAGATAGCCAAGGGGACCTTGCACAGCATTT
TGAAATCAGCAGGCCTGAAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14726.54 Da        Isoelectric Point: 4.5353

>AT91626 WP_003211020.1 NZ_CP025624:c6298729-6298328 [Pseudomonas sp. NC02]
MKFPVVIHKDADSDYSVTVPDVPGCFSAGTTFSEALDNVREALALHLEGLVADEERLPQAREVDVHLENPDFAGGVWAVI
DFDLTPYLGKSVRFNASLPEQLLNRIDERVQKDHRYASRSGFLATAALRELSV

Download         Length: 402 bp

>AT91626 NZ_CP025624:c6298729-6298328 [Pseudomonas sp. NC02]
ATGAAATTTCCAGTGGTGATACACAAAGACGCTGATTCAGATTACAGCGTGACCGTCCCGGACGTGCCAGGTTGCTTTTC
TGCGGGCACAACCTTTTCCGAAGCTCTGGATAATGTCCGCGAAGCTTTAGCGCTGCACCTCGAGGGATTGGTTGCTGATG
AGGAGCGGCTTCCTCAGGCTAGAGAGGTCGACGTCCATTTGGAGAATCCGGACTTTGCGGGTGGCGTGTGGGCGGTGATC
GACTTTGATCTTACTCCTTACCTGGGCAAGTCAGTCAGGTTCAACGCCTCACTGCCTGAGCAACTTTTGAATCGTATCGA
TGAGCGAGTGCAAAAAGACCATCGCTATGCCTCGCGCTCTGGGTTCCTGGCGACGGCGGCTTTGCGCGAACTTTCCGTTT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7Y7G6

Antitoxin

Source ID Structure
AlphaFold DB A0A2N7Y8H9

References