Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5265168..5265804 Replicon chromosome
Accession NZ_CP025624
Organism Pseudomonas sp. NC02

Toxin (Protein)


Gene name vapC Uniprot ID A0A7Y8EHL0
Locus tag C0058_RS24630 Protein ID WP_026077784.1
Coordinates 5265168..5265572 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7Y8FB80
Locus tag C0058_RS24635 Protein ID WP_008432930.1
Coordinates 5265565..5265804 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0058_RS24610 5260550..5261833 + 1284 WP_102369725.1 ABC transporter substrate-binding protein -
C0058_RS24615 5262304..5263554 + 1251 WP_023659243.1 ribonucleotide-diphosphate reductase subunit beta -
C0058_RS24620 5263700..5264413 + 714 WP_003211515.1 HNH endonuclease -
C0058_RS24625 5264485..5265126 + 642 WP_102369726.1 HAD-IB family hydrolase -
C0058_RS24630 5265168..5265572 - 405 WP_026077784.1 type II toxin-antitoxin system VapC family toxin Toxin
C0058_RS24635 5265565..5265804 - 240 WP_008432930.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C0058_RS24640 5266088..5267047 - 960 WP_102369727.1 LysR family transcriptional regulator -
C0058_RS24645 5267310..5268737 + 1428 WP_102369728.1 argininosuccinate lyase -
C0058_RS24650 5268876..5269754 + 879 WP_003211504.1 amino acid ABC transporter permease -
C0058_RS24655 5269778..5270542 + 765 WP_003211502.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5264485..5274796 10311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15129.47 Da        Isoelectric Point: 7.4662

>T91623 WP_026077784.1 NZ_CP025624:c5265572-5265168 [Pseudomonas sp. NC02]
MIKYMLDTNIVIYIIKRRPMEILEKFNANVGRMVISSITLAELMHGAEKSQFVEKNTRAVEDFISRLDVIHYDDKAAFHY
GSIRSDLEKKGTPIGVNDLHIAGHARSSGLVLVTNNEGEFKRVNGLIVENWIAA

Download         Length: 405 bp

>T91623 NZ_CP025624:c5265572-5265168 [Pseudomonas sp. NC02]
ATGATTAAGTACATGCTTGATACGAACATCGTGATCTACATCATCAAGCGTCGGCCTATGGAAATACTGGAAAAATTCAA
TGCGAATGTAGGTCGTATGGTGATCTCTTCGATCACCCTTGCGGAATTGATGCACGGGGCCGAAAAAAGCCAGTTTGTTG
AGAAAAATACTCGGGCGGTGGAGGACTTCATCTCCCGGCTTGACGTCATTCACTACGATGACAAGGCCGCTTTTCACTAC
GGCTCGATCCGCTCCGATCTCGAAAAGAAGGGCACTCCAATCGGCGTAAATGACCTGCACATCGCGGGCCACGCCAGAAG
CTCAGGATTGGTCTTGGTGACTAACAACGAAGGTGAGTTCAAGCGAGTGAATGGCTTGATCGTGGAAAACTGGATCGCCG
CCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9031.93 Da        Isoelectric Point: 4.0941

>AT91623 WP_008432930.1 NZ_CP025624:c5265804-5265565 [Pseudomonas sp. NC02]
MSTGTIFTNNRTQNIRIPADMRFPAGVKTVEVRAVGRELIISPVENTWDSFFLASESVSDDFMEERADQTQQERESFDD

Download         Length: 240 bp

>AT91623 NZ_CP025624:c5265804-5265565 [Pseudomonas sp. NC02]
ATGTCTACTGGAACGATCTTCACCAATAACCGTACACAAAATATCCGCATCCCTGCTGACATGCGTTTTCCCGCTGGGGT
GAAAACTGTAGAGGTGCGTGCCGTGGGGCGCGAACTGATTATTTCGCCGGTTGAAAACACTTGGGACAGCTTTTTCCTTG
CAAGCGAATCGGTATCTGATGATTTTATGGAGGAGCGCGCCGACCAAACCCAGCAAGAGCGAGAGTCCTTTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8EHL0

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8FB80

References