Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4730798..4731402 Replicon chromosome
Accession NZ_CP025624
Organism Pseudomonas sp. NC02

Toxin (Protein)


Gene name hicA Uniprot ID A0A829N1R9
Locus tag C0058_RS22005 Protein ID WP_003208165.1
Coordinates 4730798..4731049 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A829N1T3
Locus tag C0058_RS22010 Protein ID WP_003208166.1
Coordinates 4731046..4731402 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0058_RS22005 4730798..4731049 + 252 WP_003208165.1 type II toxin-antitoxin system HicA family toxin Toxin
C0058_RS22010 4731046..4731402 + 357 WP_003208166.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C0058_RS22015 4731403..4732575 - 1173 WP_102369571.1 MFS transporter -
C0058_RS22020 4732710..4733294 + 585 WP_102369572.1 TetR/AcrR family transcriptional regulator -
C0058_RS22025 4733592..4735103 - 1512 WP_003208170.1 multidrug efflux MFS transporter -
C0058_RS22030 4735093..4736223 - 1131 WP_003208172.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9536.03 Da        Isoelectric Point: 10.3760

>T91621 WP_003208165.1 NZ_CP025624:4730798-4731049 [Pseudomonas sp. NC02]
VSKNEKLLAKLLNEQSAFTWPELVTLLRRRGYTQIEGAGSRVRFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T91621 NZ_CP025624:4730798-4731049 [Pseudomonas sp. NC02]
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAGCAATCGGCCTTTACCTGGCCCGAACTCGTCACGCTGCT
GCGGCGCCGGGGATACACGCAAATCGAAGGGGCGGGTAGCCGGGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCCTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12788.62 Da        Isoelectric Point: 6.8428

>AT91621 WP_003208166.1 NZ_CP025624:4731046-4731402 [Pseudomonas sp. NC02]
VNNQLKHKGYIGSIEASIEDNCLFGKLLFIKALVSYEGKTVAELDAAFCTAVDDYIETCQALGQAPEKPCKGSFNVRVGH
DLHLAAALAATRQKVTLNDLTRQALNEFLQHRGALVTG

Download         Length: 357 bp

>AT91621 NZ_CP025624:4731046-4731402 [Pseudomonas sp. NC02]
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCATCGAAGACAACTGCCTGTTCGGAAAGCT
GCTTTTCATCAAGGCCCTGGTCAGCTACGAGGGTAAAACCGTCGCCGAACTGGACGCCGCCTTTTGCACCGCCGTGGACG
ACTACATCGAGACCTGCCAGGCCCTTGGGCAAGCACCGGAAAAGCCCTGCAAGGGTTCGTTCAACGTCCGTGTCGGCCAT
GACCTCCACCTGGCCGCCGCGCTTGCCGCGACCCGGCAAAAAGTCACGTTGAACGATCTCACGCGCCAGGCGCTGAACGA
ATTCCTGCAACATCGCGGCGCACTGGTGACCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829N1R9

Antitoxin

Source ID Structure
AlphaFold DB A0A829N1T3

References