Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1216788..1217303 Replicon chromosome
Accession NZ_CP025616
Organism Micrococcus luteus strain SGAir0127

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag C0205_RS05800 Protein ID WP_041103932.1
Coordinates 1217049..1217303 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag C0205_RS05795 Protein ID WP_036340860.1
Coordinates 1216788..1217048 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0205_RS05770 (C0205_11890) 1211815..1212825 - 1011 WP_119217898.1 IS481 family transposase -
C0205_RS05775 (C0205_11895) 1213109..1213519 + 411 WP_002855901.1 four-helix bundle copper-binding protein -
C0205_RS05780 (C0205_11900) 1213694..1214776 - 1083 WP_236601339.1 major royal jelly family protein -
C0205_RS05785 (C0205_11905) 1215043..1215410 - 368 Protein_1141 FAD-binding oxidoreductase -
C0205_RS05795 (C0205_11915) 1216788..1217048 + 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C0205_RS05800 (C0205_11920) 1217049..1217303 + 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
C0205_RS05805 (C0205_11925) 1217305..1217871 + 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
C0205_RS05810 (C0205_11930) 1217915..1218697 - 783 WP_070708870.1 SCO1664 family protein -
C0205_RS05815 (C0205_11935) 1218697..1219239 - 543 WP_063190266.1 DUF3090 domain-containing protein -
C0205_RS05820 (C0205_11940) 1219236..1219961 - 726 WP_262391156.1 histidine phosphatase family protein -
C0205_RS05825 (C0205_12605) 1219993..1220226 - 234 WP_148244932.1 hypothetical protein -
C0205_RS05830 (C0205_11950) 1220378..1221784 - 1407 WP_119217901.1 Dyp-type peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1211815..1212825 1010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T91615 WP_041103932.1 NZ_CP025616:1217049-1217303 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T91615 NZ_CP025616:1217049-1217303 [Micrococcus luteus]
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCAAGCGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGACGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGCCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT91615 WP_036340860.1 NZ_CP025616:1216788-1217048 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT91615 NZ_CP025616:1216788-1217048 [Micrococcus luteus]
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTAGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References