91530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3070161..3070840 Replicon chromosome
Accession NZ_CP025607
Organism Mycobacterium tuberculosis strain GG-186-10

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag C0090_RS15105 Protein ID WP_003414059.1
Coordinates 3070161..3070577 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag C0090_RS15110 Protein ID WP_003414061.1
Coordinates 3070574..3070840 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0090_RS15085 3066213..3067115 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
C0090_RS15090 3067184..3067936 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
C0090_RS15095 3068180..3068455 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
C0090_RS15100 3068452..3070074 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
C0090_RS15105 3070161..3070577 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
C0090_RS15110 3070574..3070840 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C0090_RS15115 3070866..3071261 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
C0090_RS15120 3071258..3071527 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
C0090_RS15125 3071537..3072631 - 1095 WP_102782258.1 restriction endonuclease subunit S -
C0090_RS15130 3072628..3073047 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
C0090_RS15135 3073121..3073600 - 480 WP_003414073.1 dihydrofolate reductase -
C0090_RS15140 3073671..3074471 - 801 WP_003911953.1 thymidylate synthase -
C0090_RS15145 3074627..3075364 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-123)

Antitoxin

(16-56)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T91530 WP_003414059.1 NZ_CP025607:c3070577-3070161 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

>T91530 NZ_CP025607:c3070577-3070161 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT91530 WP_003414061.1 NZ_CP025607:c3070840-3070574 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp

>AT91530 NZ_CP025607:c3070840-3070574 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5SV2


Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References