Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826212..3826897 Replicon chromosome
Accession NZ_CP025605
Organism Mycobacterium tuberculosis strain GG-134-11

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag C0083_RS18665 Protein ID WP_003417998.1
Coordinates 3826487..3826897 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0083_RS18660 Protein ID WP_003912220.1
Coordinates 3826212..3826490 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0083_RS18640 3822201..3823802 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
C0083_RS18645 3823819..3824523 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
C0083_RS18650 3824641..3825207 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
C0083_RS18655 3825269..3826156 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
C0083_RS18660 3826212..3826490 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C0083_RS18665 3826487..3826897 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
C0083_RS18670 3826930..3828666 - 1737 WP_003418002.1 cholesterol oxidase -
C0083_RS18675 3828722..3829849 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
C0083_RS18680 3829869..3831458 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T91419 WP_003417998.1 NZ_CP025605:3826487-3826897 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T91419 NZ_CP025605:3826487-3826897 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT91419 WP_003912220.1 NZ_CP025605:3826212-3826490 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT91419 NZ_CP025605:3826212-3826490 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References