Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707611..3708285 Replicon chromosome
Accession NZ_CP025605
Organism Mycobacterium tuberculosis strain GG-134-11

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag C0083_RS18200 Protein ID WP_003417282.1
Coordinates 3707611..3708039 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag C0083_RS18205 Protein ID WP_003417286.1
Coordinates 3708043..3708285 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0083_RS18175 3703433..3703834 - 402 WP_003417264.1 cytidine deaminase -
C0083_RS18180 3703975..3704409 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
C0083_RS18185 3704406..3704840 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
C0083_RS18190 3704969..3706741 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
C0083_RS18195 3706741..3707532 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
C0083_RS18200 3707611..3708039 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
C0083_RS18205 3708043..3708285 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
C0083_RS18210 3708407..3709021 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
C0083_RS18215 3709018..3709683 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
C0083_RS18220 3709684..3710217 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
C0083_RS18225 3710214..3710303 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
C0083_RS18230 3710402..3711663 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T91416 WP_003417282.1 NZ_CP025605:c3708039-3707611 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T91416 NZ_CP025605:c3708039-3707611 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT91416 WP_003417286.1 NZ_CP025605:c3708285-3708043 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT91416 NZ_CP025605:c3708285-3708043 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References