Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203587..2204131 Replicon chromosome
Accession NZ_CP025604
Organism Mycobacterium tuberculosis strain GG-129-11

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag C0091_RS10670 Protein ID WP_003409896.1
Coordinates 2203587..2203883 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag C0091_RS10675 Protein ID WP_003409899.1
Coordinates 2203880..2204131 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0091_RS10615 2198620..2198970 - 351 WP_003899096.1 hypothetical protein -
C0091_RS10620 2198981..2199883 - 903 WP_003899097.1 hypothetical protein -
C0091_RS10625 2199904..2200095 - 192 WP_003409876.1 hypothetical protein -
C0091_RS10630 2200096..2200392 - 297 WP_003409877.1 hypothetical protein -
C0091_RS10635 2200632..2200847 + 216 WP_003409878.1 antitoxin -
C0091_RS10640 2200844..2201155 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
C0091_RS21765 2201129..2201650 - 522 WP_003904745.1 hypothetical protein -
C0091_RS10650 2201625..2202002 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
C0091_RS10655 2202044..2202493 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
C0091_RS10660 2202490..2203035 + 546 WP_003899098.1 SecB-like chaperone -
C0091_RS10665 2202924..2203538 - 615 WP_003901296.1 hypothetical protein -
C0091_RS10670 2203587..2203883 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0091_RS10675 2203880..2204131 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C0091_RS10680 2204118..2204612 + 495 WP_003917554.1 hypothetical protein -
C0091_RS10685 2204772..2205179 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
C0091_RS10690 2205183..2205455 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C0091_RS10695 2205488..2206708 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
C0091_RS10710 2207607..2208404 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T91331 WP_003409896.1 NZ_CP025604:c2203883-2203587 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T91331 NZ_CP025604:c2203883-2203587 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT91331 WP_003409899.1 NZ_CP025604:c2204131-2203880 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT91331 NZ_CP025604:c2204131-2203880 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References