Detailed information of TA system TA091298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 71533..72166
• Replicon: chromosome
• Accession: NZ_CP025604
• Organism: Mycobacterium tuberculosis strain GG-129-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C0091_RS00365
• Protein ID: WP_102770464.1
• Coordinates: 71765..72166 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P0CW29
• Locus tag: C0091_RS00360
• Protein ID: WP_003400577.1
• Coordinates: 71533..71772 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0091_RS00345	66867..68306	+	1440	WP_003901784.1	FAD-binding oxidoreductase	-
C0091_RS00350	68362..68523	+	162	WP_003899796.1	hypothetical protein	-
C0091_RS00355	68564..71503	+	2940	WP_023641749.1	UPF0182 family protein	-
C0091_RS00360	71533..71772	+	240	WP_003400577.1	antitoxin VapB1	Antitoxin
C0091_RS00365	71765..72166	+	402	WP_102770464.1	type II toxin-antitoxin system ribonuclease VapC1	Toxin
C0091_RS00370	72218..74455	-	2238	WP_003899797.1	NADP-dependent isocitrate dehydrogenase	-
C0091_RS00375	74573..75142	-	570	WP_003400591.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
C0091_RS00380	75245..76156	+	912	WP_102770465.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (36-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14338.50 Da
• Isoelectric Point: 5.5777

>T91298 WP_102770464.1 NZ_CP025604:71765-72166 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKKSISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Nucleotide

• Length: 402 bp

>T91298 NZ_CP025604:71765-72166 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGAAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.84 Da
• Isoelectric Point: 8.5960

>AT91298 WP_003400577.1 NZ_CP025604:71533-71772 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Nucleotide

• Length: 240 bp

>AT91298 NZ_CP025604:71533-71772 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A829CHM7