91288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3110144..3110714 Replicon chromosome
Accession NZ_CP025603
Organism Mycobacterium tuberculosis strain GG-121-10

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag C0087_RS15320 Protein ID WP_003414166.1
Coordinates 3110144..3110500 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag C0087_RS15325 Protein ID WP_003901465.1
Coordinates 3110484..3110714 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0087_RS15300 3105596..3107284 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
C0087_RS15305 3107288..3107614 - 327 WP_003414157.1 hypothetical protein -
C0087_RS15310 3107787..3108374 + 588 WP_023641719.1 DUF3558 family protein -
C0087_RS15315 3108393..3110042 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
C0087_RS15320 3110144..3110500 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
C0087_RS15325 3110484..3110714 - 231 WP_003901465.1 antitoxin MazE Antitoxin
C0087_RS15330 3110757..3111800 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
C0087_RS15335 3111991..3112266 + 276 WP_003911993.1 DUF1778 domain-containing protein -
C0087_RS21530 3112442..3112696 - 255 WP_003917684.1 hypothetical protein -
C0087_RS15345 3112844..3113248 + 405 WP_009938577.1 hypothetical protein -
C0087_RS15350 3113245..3113436 + 192 WP_003414184.1 hypothetical protein -
C0087_RS15355 3113500..3114789 + 1290 Protein_2902 transposase family protein -
C0087_RS15360 3115023..3115280 + 258 WP_003899489.1 hypothetical protein -
C0087_RS15365 3115385..3115696 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T91288 WP_003414166.1 NZ_CP025603:c3110500-3110144 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T91288 NZ_CP025603:c3110500-3110144 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT91288 WP_003901465.1 NZ_CP025603:c3110714-3110484 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT91288 NZ_CP025603:c3110714-3110484 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References