Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2232738..2233636 Replicon chromosome
Accession NZ_CP025601
Organism Mycobacterium tuberculosis strain GG-90-10

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag C0095_RS10855 Protein ID WP_003410001.1
Coordinates 2232738..2233298 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag C0095_RS10860 Protein ID WP_003410003.1
Coordinates 2233295..2233636 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0095_RS10820 2227908..2228561 - 654 WP_003409976.1 cutinase Cfp21 -
C0095_RS10825 2228676..2228906 + 231 WP_003409980.1 DUF167 domain-containing protein -
C0095_RS10830 2228991..2229902 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
C0095_RS10835 2230011..2230610 + 600 WP_003409989.1 L-lysine exporter -
C0095_RS10840 2231026..2231453 + 428 Protein_2052 cellulose-binding protein -
C0095_RS10845 2231679..2232218 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
C0095_RS10855 2232738..2233298 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
C0095_RS10860 2233295..2233636 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
C0095_RS10865 2233722..2233979 + 258 WP_003410006.1 hypothetical protein -
C0095_RS10870 2233880..2234215 - 336 WP_003410009.1 dehydrogenase -
C0095_RS10875 2234304..2234648 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
C0095_RS10880 2234642..2234890 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
C0095_RS10885 2234990..2237305 - 2316 WP_003899120.1 cation transporter ATPase CptG -
C0095_RS10890 2237302..2237574 - 273 WP_003410017.1 DUF1490 family protein -
C0095_RS10895 2237627..2237983 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T91150 WP_003410001.1 NZ_CP025601:c2233298-2232738 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T91150 NZ_CP025601:c2233298-2232738 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT91150 WP_003410003.1 NZ_CP025601:c2233636-2233295 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT91150 NZ_CP025601:c2233636-2233295 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References