Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1764763..1765376 Replicon chromosome
Accession NZ_CP025601
Organism Mycobacterium tuberculosis strain GG-90-10

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag C0095_RS08570 Protein ID WP_003407786.1
Coordinates 1764972..1765376 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag C0095_RS08565 Protein ID WP_009935474.1
Coordinates 1764763..1764966 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0095_RS08535 1760168..1760548 + 381 WP_003407768.1 fumarate reductase subunit C -
C0095_RS08540 1760545..1760922 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
C0095_RS08545 1760990..1761598 + 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
C0095_RS08550 1761782..1762930 + 1149 Protein_1614 MMPL family transporter -
C0095_RS08555 1762940..1763386 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
C0095_RS08560 1763421..1764710 + 1290 WP_003407781.1 threonine ammonia-lyase -
C0095_RS08565 1764763..1764966 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C0095_RS08570 1764972..1765376 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
C0095_RS08575 1765393..1767135 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
C0095_RS08580 1767128..1769425 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T91143 WP_003407786.1 NZ_CP025601:1764972-1765376 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T91143 NZ_CP025601:1764972-1765376 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT91143 WP_009935474.1 NZ_CP025601:1764763-1764966 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp

>AT91143 NZ_CP025601:1764763-1764966 [Mycobacterium tuberculosis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References