Detailed information of TA system TA091055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 363241..363767
• Replicon: chromosome
• Accession: NZ_CP025600
• Organism: Mycobacterium tuberculosis strain GG-77-11

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: C0088_RS01635
• Protein ID: WP_003401560.1
• Coordinates: 363465..363767 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: C0088_RS01630
• Protein ID: WP_003401555.1
• Coordinates: 363241..363468 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0088_RS01615	358934..359737	-	804	WP_003401540.1	hypothetical protein	-
C0088_RS01620	359747..361144	-	1398	WP_003401544.1	sulfatase	-
C0088_RS01625	361323..363098	+	1776	WP_010886074.1	PE family protein	-
C0088_RS01630	363241..363468	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
C0088_RS01635	363465..363767	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
C0088_RS01640	363815..364036	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
C0088_RS01645	364033..364458	+	426	WP_003401566.1	PIN domain nuclease	-
C0088_RS01650	364594..365226	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
C0088_RS01655	365223..366131	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T91055 WP_003401560.1 NZ_CP025600:363465-363767 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T91055 NZ_CP025600:363465-363767 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT91055 WP_003401555.1 NZ_CP025600:363241-363468 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT91055 NZ_CP025600:363241-363468 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1