91048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3183110..3183797 Replicon chromosome
Accession NZ_CP025599
Organism Mycobacterium tuberculosis strain GG-45-11

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag C0094_RS15705 Protein ID WP_003414624.1
Coordinates 3183354..3183797 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag C0094_RS15700 Protein ID WP_003414620.1
Coordinates 3183110..3183367 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0094_RS15680 3178430..3179284 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
C0094_RS15685 3179340..3180503 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
C0094_RS15690 3180520..3181734 - 1215 WP_003899518.1 zinc metalloprotease Rip -
C0094_RS15695 3181742..3182983 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
C0094_RS15700 3183110..3183367 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
C0094_RS15705 3183354..3183797 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
C0094_RS15710 3183877..3184539 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
C0094_RS15715 3184635..3184826 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C0094_RS15720 3185158..3186906 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
C0094_RS15725 3187002..3187583 + 582 WP_003414644.1 fasciclin domain-containing protein -
C0094_RS15730 3187683..3187949 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(2-38)


Sequences


Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T91048 WP_003414624.1 NZ_CP025599:3183354-3183797 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T91048 NZ_CP025599:3183354-3183797 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT91048 WP_003414620.1 NZ_CP025599:3183110-3183367 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT91048 NZ_CP025599:3183110-3183367 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7VWO


Antitoxin

Source ID Structure
AlphaFold DB G0TFH0

References