Detailed information of TA system TA091003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 710741..711366
• Replicon: chromosome
• Accession: NZ_CP025599
• Organism: Mycobacterium tuberculosis strain GG-45-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C0094_RS03315
• Protein ID: WP_102800681.1
• Coordinates: 710965..711366 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ36
• Locus tag: C0094_RS03310
• Protein ID: WP_003403213.1
• Coordinates: 710741..710968 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C0094_RS03280	705920..706141	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
C0094_RS03285	706283..706888	+	606	WP_003898526.1	hypothetical protein	-
C0094_RS03290	706907..709474	-	2568	WP_003900188.1	SEC-C domain-containing protein	-
C0094_RS03295	709558..710307	+	750	WP_003898528.1	hypothetical protein	-
C0094_RS03300	710304..710546	+	243	WP_003403210.1	hypothetical protein	-
C0094_RS03310	710741..710968	+	228	WP_003403213.1	antitoxin VapB29	Antitoxin
C0094_RS03315	710965..711366	+	402	WP_102800681.1	type II toxin-antitoxin system ribonuclease VapC29	Toxin
C0094_RS21630	711495..712190	+	696	WP_003900189.1	galactose-1-phosphate uridylyltransferase	-
C0094_RS21635	712187..712678	+	492	WP_012054156.1	galactose-1-phosphate uridylyltransferase	-
C0094_RS03325	712675..713766	+	1092	WP_003906403.1	galactokinase	-
C0094_RS03335	714161..715225	+	1065	WP_003898532.1	hypothetical protein	-
C0094_RS03340	715329..716276	+	948	WP_003403232.1	DUF732 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13959.82 Da
• Isoelectric Point: 6.2017

>T91003 WP_102800681.1 NZ_CP025599:710965-711366 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARHVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Nucleotide

• Length: 402 bp

>T91003 NZ_CP025599:710965-711366 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGCATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8163.17 Da
• Isoelectric Point: 5.6307

>AT91003 WP_003403213.1 NZ_CP025599:710741-710968 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Nucleotide

• Length: 228 bp

>AT91003 NZ_CP025599:710741-710968 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BSC9