Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770687..3771216 Replicon chromosome
Accession NZ_CP025596
Organism Mycobacterium tuberculosis strain GG-27-11

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag C0082_RS18435 Protein ID WP_003417760.1
Coordinates 3770959..3771216 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag C0082_RS18430 Protein ID WP_003417757.1
Coordinates 3770687..3770962 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0082_RS21915 3767485..3768922 - 1438 Protein_3472 FAD-binding oxidoreductase -
C0082_RS18415 3769025..3769414 + 390 WP_003417745.1 DUF732 domain-containing protein -
C0082_RS18420 3769428..3769721 - 294 WP_003417749.1 DUF3017 domain-containing protein -
C0082_RS18425 3769718..3770563 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
C0082_RS18430 3770687..3770962 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
C0082_RS18435 3770959..3771216 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
C0082_RS18440 3771258..3772448 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
C0082_RS18445 3772565..3772933 + 369 WP_003417765.1 FHA domain-containing protein -
C0082_RS18450 3772930..3773481 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
C0082_RS18455 3773488..3774069 - 582 WP_003417769.1 ATP/GTP-binding protein -
C0082_RS18460 3774050..3774418 - 369 WP_003417772.1 DUF742 domain-containing protein -
C0082_RS18465 3774396..3774788 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T90869 WP_003417760.1 NZ_CP025596:3770959-3771216 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T90869 NZ_CP025596:3770959-3771216 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT90869 WP_003417757.1 NZ_CP025596:3770687-3770962 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT90869 NZ_CP025596:3770687-3770962 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References