Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2232648..2233546 Replicon chromosome
Accession NZ_CP025596
Organism Mycobacterium tuberculosis strain GG-27-11

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag C0082_RS10850 Protein ID WP_003410001.1
Coordinates 2232648..2233208 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag C0082_RS10855 Protein ID WP_003410003.1
Coordinates 2233205..2233546 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0082_RS10815 2227817..2228470 - 654 WP_003409976.1 cutinase Cfp21 -
C0082_RS10820 2228585..2228815 + 231 WP_003409980.1 DUF167 domain-containing protein -
C0082_RS10825 2228900..2229811 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
C0082_RS10830 2229920..2230519 + 600 WP_003409989.1 L-lysine exporter -
C0082_RS10835 2230935..2231363 + 429 WP_003409992.1 cellulose-binding protein -
C0082_RS10840 2231589..2232128 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
C0082_RS10850 2232648..2233208 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
C0082_RS10855 2233205..2233546 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
C0082_RS10860 2233632..2233889 + 258 WP_003410006.1 hypothetical protein -
C0082_RS10865 2233790..2234125 - 336 Protein_2054 dehydrogenase -
C0082_RS10870 2234214..2234558 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
C0082_RS10875 2234552..2234800 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
C0082_RS10880 2234900..2237215 - 2316 WP_003899120.1 cation transporter ATPase CptG -
C0082_RS10885 2237212..2237484 - 273 WP_003410017.1 DUF1490 family protein -
C0082_RS10890 2237537..2237893 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T90846 WP_003410001.1 NZ_CP025596:c2233208-2232648 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T90846 NZ_CP025596:c2233208-2232648 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT90846 WP_003410003.1 NZ_CP025596:c2233546-2233205 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT90846 NZ_CP025596:c2233546-2233205 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References