90808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770766..3771295 Replicon chromosome
Accession NZ_CP025595
Organism Mycobacterium tuberculosis strain GG-20-11

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag C0093_RS18410 Protein ID WP_003417760.1
Coordinates 3771038..3771295 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag C0093_RS18405 Protein ID WP_003417757.1
Coordinates 3770766..3771041 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0093_RS21860 3767564..3769001 - 1438 Protein_3469 FAD-binding oxidoreductase -
C0093_RS18390 3769104..3769493 + 390 WP_003417745.1 DUF732 domain-containing protein -
C0093_RS18395 3769507..3769800 - 294 WP_003417749.1 DUF3017 domain-containing protein -
C0093_RS18400 3769797..3770642 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
C0093_RS18405 3770766..3771041 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
C0093_RS18410 3771038..3771295 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
C0093_RS18415 3771337..3772527 + 1191 WP_012054356.1 NADH:flavin oxidoreductase -
C0093_RS18420 3772644..3773012 + 369 WP_003417765.1 FHA domain-containing protein -
C0093_RS18425 3773009..3773560 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
C0093_RS18430 3773567..3774148 - 582 WP_003417769.1 ATP/GTP-binding protein -
C0093_RS18435 3774129..3774497 - 369 WP_003417772.1 DUF742 domain-containing protein -
C0093_RS18440 3774475..3774867 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T90808 WP_003417760.1 NZ_CP025595:3771038-3771295 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T90808 NZ_CP025595:3771038-3771295 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT90808 WP_003417757.1 NZ_CP025595:3770766-3771041 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT90808 NZ_CP025595:3770766-3771041 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References