90730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402146..2402675 Replicon chromosome
Accession NZ_CP025594
Organism Mycobacterium tuberculosis strain GG-5-10

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag C0085_RS11665 Protein ID WP_003411124.1
Coordinates 2402146..2402463 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag C0085_RS11670 Protein ID WP_003411127.1
Coordinates 2402460..2402675 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0085_RS11635 2397283..2398359 + 1077 WP_030030054.1 hypothetical protein -
C0085_RS11640 2398356..2398637 + 282 WP_003411112.1 hypothetical protein -
C0085_RS11645 2398673..2399746 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
C0085_RS11650 2399751..2400281 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
C0085_RS11655 2400329..2401675 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
C0085_RS11665 2402146..2402463 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0085_RS11670 2402460..2402675 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
C0085_RS11675 2402930..2403988 + 1059 WP_003411129.1 hypothetical protein -
C0085_RS11680 2404118..2404474 - 357 WP_003411130.1 hypothetical protein -
C0085_RS11685 2404569..2405351 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
C0085_RS11690 2405619..2405909 - 291 WP_003900476.1 YggT family protein -
C0085_RS11695 2406071..2406727 - 657 WP_003411133.1 cell division protein SepF -
C0085_RS11700 2406793..2407569 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T90730 WP_003411124.1 NZ_CP025594:c2402463-2402146 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T90730 NZ_CP025594:c2402463-2402146 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT90730 WP_003411127.1 NZ_CP025594:c2402675-2402460 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT90730 NZ_CP025594:c2402675-2402460 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References