90722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203630..2204174 Replicon chromosome
Accession NZ_CP025594
Organism Mycobacterium tuberculosis strain GG-5-10

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag C0085_RS10670 Protein ID WP_003409896.1
Coordinates 2203630..2203926 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag C0085_RS10675 Protein ID WP_003409899.1
Coordinates 2203923..2204174 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0085_RS10615 2198663..2199013 - 351 WP_003899096.1 hypothetical protein -
C0085_RS10620 2199024..2199926 - 903 WP_003899097.1 hypothetical protein -
C0085_RS10625 2199947..2200138 - 192 WP_003409876.1 hypothetical protein -
C0085_RS10630 2200139..2200435 - 297 WP_003409877.1 hypothetical protein -
C0085_RS10635 2200675..2200890 + 216 WP_003409878.1 antitoxin -
C0085_RS10640 2200887..2201198 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
C0085_RS21780 2201172..2201693 - 522 WP_003904745.1 hypothetical protein -
C0085_RS10650 2201668..2202045 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
C0085_RS10655 2202087..2202536 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
C0085_RS10660 2202533..2203078 + 546 WP_003409891.1 SecB-like chaperone -
C0085_RS10665 2202967..2203581 - 615 WP_003901296.1 hypothetical protein -
C0085_RS10670 2203630..2203926 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C0085_RS10675 2203923..2204174 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C0085_RS10680 2204161..2204655 + 495 WP_003899099.1 hypothetical protein -
C0085_RS10685 2204815..2205222 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
C0085_RS10690 2205226..2205498 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C0085_RS10695 2205531..2206751 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
C0085_RS10710 2207650..2208447 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-93)

Antitoxin

(2-80)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T90722 WP_003409896.1 NZ_CP025594:c2203926-2203630 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T90722 NZ_CP025594:c2203926-2203630 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT90722 WP_003409899.1 NZ_CP025594:c2204174-2203923 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT90722 NZ_CP025594:c2204174-2203923 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TLU9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References