90718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1946976..1947589 Replicon chromosome
Accession NZ_CP025594
Organism Mycobacterium tuberculosis strain GG-5-10

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag C0085_RS09400 Protein ID WP_003408465.1
Coordinates 1946976..1947365 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag C0085_RS09405 Protein ID WP_003408469.1
Coordinates 1947362..1947589 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0085_RS09370 1942605..1943519 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
C0085_RS09375 1943522..1944352 + 831 WP_003916363.1 cyclase family protein -
C0085_RS09380 1944352..1944702 + 351 WP_003898986.1 cupin domain-containing protein -
C0085_RS09385 1944755..1945573 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
C0085_RS09390 1945587..1946366 + 780 WP_003408460.1 IclR family transcriptional regulator -
C0085_RS09400 1946976..1947365 - 390 WP_003408465.1 PIN domain-containing protein Toxin
C0085_RS09405 1947362..1947589 - 228 WP_003408469.1 antitoxin Antitoxin
C0085_RS09410 1947807..1949291 + 1485 WP_003408473.1 carboxylase -
C0085_RS09415 1949288..1950535 + 1248 WP_003408476.1 serine hydrolase -
C0085_RS09420 1950578..1950997 - 420 WP_003408483.1 hypothetical protein -
C0085_RS09425 1950987..1951697 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-116)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T90718 WP_003408465.1 NZ_CP025594:c1947365-1946976 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T90718 NZ_CP025594:c1947365-1946976 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT90718 WP_003408469.1 NZ_CP025594:c1947589-1947362 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT90718 NZ_CP025594:c1947589-1947362 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References