Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 840910..841619 Replicon chromosome
Accession NZ_CP025594
Organism Mycobacterium tuberculosis strain GG-5-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C0085_RS04065 Protein ID WP_031748852.1
Coordinates 841191..841619 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C0085_RS04060 Protein ID WP_102765644.1
Coordinates 840910..841167 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C0085_RS04055 838414..840819 + 2406 WP_012054160.1 PE family protein -
C0085_RS04060 840910..841167 + 258 WP_102765644.1 ribbon-helix-helix protein, CopG family Antitoxin
C0085_RS04065 841191..841619 + 429 WP_031748852.1 type II toxin-antitoxin system VapC family toxin Toxin
C0085_RS04070 841709..841883 - 175 Protein_781 transposase -
C0085_RS04075 841996..842241 + 246 WP_003403841.1 hypothetical protein -
C0085_RS04080 842310..843194 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
C0085_RS04085 843205..844377 - 1173 WP_003403845.1 acyl-CoA dehydrogenase FadE9 -
C0085_RS04090 844384..845916 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15874.29 Da        Isoelectric Point: 7.5536

>T90706 WP_031748852.1 NZ_CP025594:841191-841619 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRAEAFAFVEAVNAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T90706 NZ_CP025594:841191-841619 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9087.25 Da        Isoelectric Point: 8.9952

>AT90706 WP_102765644.1 NZ_CP025594:840910-841167 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNTVLSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT90706 NZ_CP025594:840910-841167 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTAACCTCGAATACGGTGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References