Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 81043..81655 Replicon plasmid pCBA4604-01
Accession NZ_CP025584
Organism Paracoccus jeotgali strain CBA4604

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CYR75_RS15410 Protein ID WP_101501144.1
Coordinates 81260..81655 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CYR75_RS15405 Protein ID WP_101501143.1
Coordinates 81043..81270 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYR75_RS15380 76495..76728 - 234 WP_101501141.1 hypothetical protein -
CYR75_RS15385 76728..78692 - 1965 WP_101501142.1 calcium-binding protein -
CYR75_RS15395 80070..80225 - 156 WP_101500817.1 DUF1127 domain-containing protein -
CYR75_RS15400 80524..80847 - 324 Protein_78 IS5/IS1182 family transposase -
CYR75_RS15405 81043..81270 + 228 WP_101501143.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CYR75_RS15410 81260..81655 + 396 WP_101501144.1 PIN domain-containing protein Toxin
CYR75_RS15415 81971..82354 - 384 WP_158644695.1 hypothetical protein -
CYR75_RS15420 82459..83956 - 1498 Protein_82 IS66 family transposase -
CYR75_RS15425 84016..84360 - 345 Protein_83 IS66 family insertion sequence element accessory protein TnpB -
CYR75_RS15430 84357..84752 - 396 WP_101498326.1 transposase -
CYR75_RS15435 85030..86058 - 1029 WP_158644696.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..149225 149225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-113)

Antitoxin

SpoVT-AbrB domain

(5-42)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14535.58 Da        Isoelectric Point: 4.2585

>T90626 WP_101501144.1 NZ_CP025584:81260-81655 [Paracoccus jeotgali]
MSVEFAVTNVILYLLDEGPKADRAEEILANGPRISVQVLNEALVNCRRKAGLDWDETGVFLTGIQTLCTVEDLTVQTHQV
GRALAERYQFSVYDAMIVAAALLSGCTTLWSEDMHDGLLVEDQLRIVNPFH

Download         Length: 396 bp

>T90626 NZ_CP025584:81260-81655 [Paracoccus jeotgali]
ATGAGCGTTGAATTCGCCGTTACCAATGTGATCCTGTATCTCCTCGACGAGGGGCCGAAAGCGGACCGGGCCGAAGAGAT
ACTGGCGAACGGGCCGCGGATCAGCGTGCAGGTGCTGAACGAAGCCCTGGTCAACTGCCGCAGAAAGGCGGGCCTTGATT
GGGACGAGACAGGGGTTTTCCTCACCGGCATCCAGACGTTGTGCACCGTCGAGGATCTGACCGTACAAACCCATCAGGTG
GGACGCGCCTTGGCCGAGCGCTACCAGTTCTCTGTTTATGACGCCATGATCGTCGCTGCGGCACTGCTCTCCGGCTGCAC
GACCTTGTGGAGCGAGGACATGCACGATGGCCTGCTCGTGGAAGATCAACTCCGCATCGTCAATCCGTTTCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8709.99 Da        Isoelectric Point: 11.3558

>AT90626 WP_101501143.1 NZ_CP025584:81043-81270 [Paracoccus jeotgali]
MQVSKWGNSLAVRLPVKLLRELGLKEGDRIDFRKDDGAVLVRRQPEAEQVLQELRGFRGRLPRQDRLSRDAANER

Download         Length: 228 bp

>AT90626 NZ_CP025584:81043-81270 [Paracoccus jeotgali]
ATGCAGGTGTCGAAATGGGGCAACTCCCTTGCGGTCCGATTGCCGGTCAAACTCCTCCGGGAGCTGGGATTGAAGGAGGG
GGATCGGATCGATTTCAGGAAGGATGATGGTGCGGTTCTGGTTCGGCGCCAGCCGGAGGCCGAGCAGGTGCTGCAGGAAC
TGCGTGGGTTCCGCGGCAGGTTGCCGAGGCAGGACCGCCTGAGCCGCGACGCAGCGAATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References